Preventive and Curative Effects of Gyokuheifu-san, a Formula of Traditional Chinese Medicine, on Allergic Rhinitis Induced with Japanese Cedar Pollens in Guinea Pig (Pharmacognosy)
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概要
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Gyokuheifu-san (GHS ; Jade Windscreen Powder in English, Yupingfeng-san in Chinese) is an herbal formula in traditional Chinese medicine that consolidates the superficial resistance to protect from invasion by external pathogenic influences. We evaluated the preventive and curative effects of GHS on allergic rhinitis induced by Japanese cedar pollens in guinea pigs, since the pollen can be considered one of external pathogens indicated by GHS. Guinea pigs were sensitized by intranasal instillation of cedar pollen extract with alum twice a day for 7 d, and the animals were then forced to inhale the pollens for challenge once a week for 5 weeks. We administered GHS once a day for 2 weeks in the period of sensitization to evaluate its preventive effect, or for 2 weeks from the 2nd to the 4th week of pollen inhalation, once pollinosis had begun, to evaluate its curative effect on allergic rhinitis. GHS significantly suppressed the frequency of sneezing induced by pollens and tended to reduce nosescratching behavior after ceasing its administration in both designs of medicinal treatment. Tranilast, which is an anti-allergic drug we used as a positive control, could not suppress these rhinitic symptoms. GHS appears to have non-symptomatic and non-allopathic effects on allergic rhinitis. Our results suggest that traditional medicines have their own characteristics different from modern medicines, and the original pharmacological experiments are important to evaluate traditional medicines scientifically.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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ITO Yoshiaki
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Kano Y
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Ito Yoshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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佐々木 茂貴
Faculty Of Pharmaceutical Sciences Kyushu University
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MAKINO Toshiaki
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Makino T
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sci. Nagoya City Univ.
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Makino Toshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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SASAKI Shin-ya
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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FUJIMURA Yuu
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Kano Yoshihiro
Iskra Industry Co. Ltd.
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Fujimura Yuu
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Makino Toshiaki
Department Of Chemistry Faculty Of Science Okayam University Of Science
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Makino Taketoshi
R&d Center Sunstar Inc.
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Makino Toshiaki
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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