Antiviral Sulfated Polysaccharide from Navicula directa, a Diatom Collected from Deep-Sea Water in Toyama Bay(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC_<50>/IC_<50>) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.
- 2006-10-01
著者
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Hayashi Kyoko
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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Hayashi Toshimitsu
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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Lee Jung-Bum
Graduate School of Medicine and Pharmaceutical Sciences for Research
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Lee Jung-bum
富山大学 大学院医学薬学研究部
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Lee Jung-bum
Faculty Of Pharmaceutical Sciences University Of Toyama
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Lee J‐b
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
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Suzuki Eiko
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Hayashi Kyoko
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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HIRATA Megumi
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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KURODA Eiko
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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KUBO Yoshihiro
Toyama Prefectural Institute for Pharmaceutical Research
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
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Hayashi T
Faculty Of Pharmaceutical Sciences Josai University
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Kuroda Eiko
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Hirata Megumi
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Kano Yoshihiro
Iskra Industry Co. Ltd.
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Hayashi K
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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Kubo Yoshihiro
Iskra Industry Co. Ltd.
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Hayashi Kyoko
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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