Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes from Pimpinella anisum
スポンサーリンク
概要
- 論文の詳細を見る
Three antiviral and immunostimulating substances (LC1, LC2 and LC3) were isolated from a hot water extract of seeds of Pimpinella anisum by combination of anion-exchange, gel filtration and hydrophobic interaction column chromatographies. Chemical and spectroscopic analyses revealed them to be lignin-carbohydrate-protein complexes. These lignin-carbohydrate complexes (LCs) showed antiviral activities against herpes simplex virus types 1 and 2 (HSV-1 and -2), human cytomegalovirus (HCMV) and measles virus. LCs were also found to interfere with virus adsorption to the host cell surface and directly inactivate viruses. Furthermore, they enhanced nitric oxide (NO) production by inducing iNOS mRNA and protein expression in RAW 264.7 murine macrophage cells. The induced mRNA expression of cytokines including IL-1β and IL-10 was also apparent. These results suggest that the lignin-carbohydrate-protein complexes from P. anisum possessed potency as functional food ingredients against infectious diseases.
- 2011-03-23
著者
-
Hayashi Kyoko
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
-
Lee Jung-Bum
Graduate School of Medicine and Pharmaceutical Sciences for Research
-
Lee Jung-bum
富山大学 大学院医学薬学研究部
-
Lee Jung-bum
Faculty Of Pharmaceutical Sciences University Of Toyama
-
Lee J‐b
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
-
Hayashi Kyoko
Faculty Of Medicine Toyama Medical And Pharmaceutical University
-
Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
-
Hayashi T
Faculty Of Pharmaceutical Sciences Josai University
-
YAMAGISHI Chihiro
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
-
Hayashi K
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
-
Yamagishi Chihiro
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
-
Hayashi Kyoko
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
関連論文
- Characterization of Structures and Antiviral Effects of Polysaccharides from Portulaca oleracea L.
- Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus
- Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
- Evaluation of an Edible Blue-Green Alga, Aphanothece sacrum, for Its Inhibitory Effect on Replication of Herpes Simplex Virus Type 2 and Influenza Virus Type A
- Resistance of human brain microvascular endothelial cells in culture to methylmercury : cell-density-dependent defense mechanisms
- Suppression of fibroblast growth factor-2 expression : Possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells
- Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells
- Homocysteine Inhibits Proteoglycan Synthesis in Cultured Bovine Aortic Smooth Muscle Cells
- Methylmercury Retards the Repair of Wounded Monolayer of Human Brain Microvascular Endothelial Cells by Inhibiting Their Proliferation without Nonspecific Cell Damage
- Proteoglycans Released from Cultured Bovine Aortic Endothelial Cell Layers by Sodium Spirulan Are Both Perlecan and Biglycan(Biochemistry/Molecular Biology)
- Stimulation of Proteoglycan Release from Cultured Vascular Endothelial Cell Layers by Sodium Spirulan
- Inhibition of the Association of Proteoglycans with Cultured Vascular Endothelial Cell Layers by Calcium and Sodium Spirulan
- Reaction of 1-azabicyclobutane with activated amides
- Synthesis and Reaction of 1-Azabicyclo[3.1.0]hexane
- Intramolecular Nonbonded S…N Interaction in Rabeprazole
- Synthesis of New Quinolone Antibiotics Utilizing Azetidine Derivatives Obtained from 1-Azabicyclo[1.1.0]butane
- Effects of Magnesium Salts and Amines on the Stereoselectivity in the Imine Aldol Reaction
- Mechanistic Considerations for the Consecutive Cyclization of 2,3-Dibromopropylamine Hydrobromide Giving a Strained Molecule, 1-Azabicyclo[1.1.0]butane
- Synthesis of New Chiral Sulfinyldiacetic Acid Derivatives and Attempt at Chemoselective Asymmetric Pummerer Reaction
- Geranylgeranyl Diphosphate Synthase from Scoparia dulcis and Croton sublyratus. Plastid Localization and Conversion to a Farnesyl Diphosphate Synthase by Mutagenesis
- Involvement of 2-C-Methyl-D-erythritol-4-phosphate Pathway in Biosynthesis of Aphidicolin-Like Tetracyclic Diterpene of Scoparia dulcis
- Anti-herpes Simplex Virus Target of an Acidic Polysaccharide, Nostoflan, from the Edible Blue-Green Alga Nostoc flagelliforme(Pharmacognosy)
- Effect of l-Menthol-Ethanol-Water System on the Systemic Absorption of Flurbiprofen after Repeated Topical Applications in Rabbits
- Phenoxazine Derivatives Inactivate Human Cytomegalovirus, Herpes Simplex Virus-1, and Herpes Simplex Virus-2 In Vitro
- Isolation of Sulfated Galactan from Codium fragile and Its Antiviral Effect
- Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga Sargassum micracanthum, and a New Chromene Derivative Converted from the Plastoquinones(Pharmacognosy)
- pH Lowering in Liposomal Dispersiond Induced by Phospholipid Peroxidation
- Alkyl Chain Length Dependency in Hydrolysis of Liposomal Phosphatidylcholine by Dialkylphosphate
- Cloning and Expression of Calmodulin Gene in Scoparia dulcis(Pharmacognosy)
- Antiviral Sulfated Polysaccharide from Navicula directa, a Diatom Collected from Deep-Sea Water in Toyama Bay(Pharmacognosy)
- Selective Enhancement of Scopadulcic Acid B Production in the Cultured Tissues of Scoparia dulcis by Methyl Jasmonate
- Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
- Analysis of Skin Disposition and Metabolism of Ethyl Nicotinate after Topical Application Using Dual Agar Gel Disc-Inserted Rats(Biopharmacy)
- Analysis of Skin Disposition of Flurbiprofen after Topical Application Using Dual Agar Gel Discs-Inserted Rats(Biopharmacy)
- Pharmacokinetic Profile of Flavin Adenine Dinucleotide, Flavin Mononucleotide and Riboflavin Following Intravenous Administration of Riboflavin or Its Coenzymes in Rats
- Utility of a Three-Dimensional Cultured Human Skin Model as a Tool to Evaluate the Simultaneous Diffusion and Metabolism of Ethyl Nicotinate in Skin
- Skin Disposition of Drugs after Topical Application in Hairless Rats
- Effects of Plastoquinones from the Brown Alga Sargassum micracanthum and a New Chromene Derivative Converted from the Plastoquinones on Acute Gastric Lesions in Rats(Pharmacognosy)
- New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum
- Hydrolysis Rates of Olive Oil by Lipase in a Monodispersed O/W Emulsion System Using Membrane Emulsification
- Inhibition of Cultured Bovine Aortic Smooth Muscle Cell Proliferation by Colominic Acid(Pharmacology)
- Differential Effects of Sodium Spirulan on the Secretion of Fibrinolytic Proteins from Vascular Endothelial Cells : Enhancement of Plasminogen Activator Activity
- Novel Antiviral Fucoidan from Sporophyll of Undaria pinnatifida (Mekabu)
- A Novel Antivirally Active Fucan Sulfate Derived from an Edible Brown Alga, Sargassum horneri
- Effects of Structural Modification of Calcium Spirulan, a Sulfated Polysaccharide from Spirulina Platensis, on Antiviral Activity
- An Antivirally Active Sulfated Polysaccharide from Sargassum horneri (TURNER) C.AGARDH
- Effects of Incorporation of Various Amphiphiles into Recipient Liposome Membraneson Inter-Membrane Protein Transfer
- Geranylgeranyl Diphosphate Synthases from Scoparia dulcis and Croton sublyratus. cDNA Cloning, Functional Expression, and Conversion to a Farnesyl Diphosphate Synthase
- Inhibitory Activities of Plastoquinones and Chromene Derivative from a Brown Alga Sagassum micracanthum on Bone Resorption(Pharmacognosy)
- Antiviral Targets of a Chromene Derivative from Sargassum micracanthum in the Replication of Human Cytomegalovirus(Microbiology)
- Conversion of FAD to FMN and Riboflavin in Plasma : Effects of Measuring Method(Biopharmacy)
- Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes from Pimpinella anisum
- Cloning and Characterization of Sdga Gene Encoding α-Subunit of Heterotrimeric Guanosine 5'-Triphosphate-Binding Protein Complex in Scoparia dulcis(Pharmacognosy)
- Development of a Membrane Fusible Drug Carrier from Erythrocytes by the Spontaneous Transfer of Viral Fusion Protein from Influenza Virus-Infected Cells
- Evaluation of an Edible Blue-Green Alga, Aphanothece sacrum, for Its Inhibitory Effect on Replication of Herpes Simplex Virus Type 2 and Influenza Virus Type A
- In Vitro Characterization of the Cytochrome P450 Isoforms Involved in the Metabolism of 6-Methoxy-2-napthylacetic Acid, an Active Metabolite of the Prodrug Nabumetone
- Two new monoterpenes from Sibiraea angustata
- Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes from Pimpinella anisum
- Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
- Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
- Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses
- Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions