Intramolecular Nonbonded S…N Interaction in Rabeprazole

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概要

• 論文の詳細を見る

• Intramolecular nonbonded S…N interactions in the crystal structures of the derivatives (7a-d) of sodium rabeprazole (1) and an intermolecular nonbonded S…N interaction between ethylmethylsulfoxide and pyridine in a solution were recognized. These results made us estimate that the intramolecular nonbonded S…N interaction existed in 1 and its derivatives in a solution, and formed the 4-membered quasi-ring in 2 (Fig. 1) followed by the increase of the reactivity of 2 to give the putative spiro sulfoxide 3, which is the key intermediate in the reaction cascade of 1 (Chart 1).

• 社団法人日本薬学会の論文
• 2008-06-01

著者

• SHIRO Motoo

  Rigaku Corporation X-ray Research Laboratory

• Shiro Motoo

  Rigaku Corporation

• Shiro M

  Rigaku Corp. Tokyo

• Hayashi Kazuhiko

  College of Pharmacy, Kinjo Gakuin University

• Sano Shigeki

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• Nagao Yoshimitsu

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• OGAWA Shiho

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• YAMAGUCHI Kentaro

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunnri University

• SEI Yoshihisa

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunnri University

• Ogawa Shiho

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 佐野 茂樹

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 佐野 茂樹

  徳島大学薬学部

• Sano Shigeki

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Hayashi Kyoko

  Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Sei Yoshihisa

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunnri University

• 長尾 善光

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  徳島大学薬学部

• Nagao Yoshimitsu

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Y

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Yoshimitsu

  Faculity Of Pharmaceutical Sciences The University Of Tokushima

• Yamaguchi Kentaro

  Faculity Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University

• Shiro M

  Rigaku Corporation

• Suzuki Mitsuko

  Institute For Chemical Research Kyoto University

• Yamaguchi Kentaro

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunnri University

• Masuoka S

  Takara Agri Co. Ltd.

• Shiro Motoo

  Rigaku Co.

• Shiro Motoo

  Shionogi Research Laboratry Shionogi & Co. Ltd.

• Hayashi K

  Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama

• Mito S

  Institute For Chemical Research Kyoto University

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