Differential Contribution of Metal Complexation and Dimerization to the Chemotherapeutic Potential of Bicyclen-Zn^<II>_2 Complex against Human Immunodeficiency Virus

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概要

• 論文の詳細を見る

• 1,1'-(m-Xylenediyl)-bis (1,4,7,10-tetraazacyclododecane)-Zn^<II>_2 complex (m-xylenediyl-bicyclen-Zn^<II>_2), a potent inhibitor of human immunodeficiency virus (HIV), was obtained from cyclen by a combination of dimerization and metal complexation. The ratio of median cytotoxic concentration against host cells (CC_<50>) and median effective concentration against HIV cytopathogenicity (EC_<50>), referred to as the selectivity index (SI), was regarded to be a measure of anti-HIV activity. These two chemical modifications contributed to a potent, in vitro anti-HIV activity of m-xylenediyl-bicyclen-Zn^<II>_2 by respectively increasing the CC_<50> and decreasing the EC_<50> in comparison with those of cyclen.

• 公益社団法人日本薬学会の論文
• 1996-03-15

著者

• Shiro M

  Rigaku Corp. Tokyo

• Fujioka Haruto

  Hiroshima University School Of Medicine

• Kimura E

  Hiroshima Univ. Hiroshima Jpn

• Koike T

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• YOSHIDA Tetsuya

  Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University

• Inouye Yoshio

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine:(present Address)toho U

• KANAMORI Tatsuyuki

  Institute of Pharmaceutical Sciences Hiroshima University School of Medicine

• KOIKE Tohru

  Institute of Pharmaceutical Sciences Hiroshima University School of Medicine

• SHIONOYA Mitsuhiko

  Institute of Pharmaceutical Sciences Hiroshima University School of Medicine

• KIMURA Eiichi

  Institute of Pharmaceutical Sciences Hiroshima University School of Medicine

• Shiro M

  Rigaku Corporation

• Suzuki Mitsuko

  Institute For Chemical Research Kyoto University

• Inouye Yoshio

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• Kimura E

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Yoshida Tetsuya

  Department Of Microbiology And Immunology Aichi Medical University School Of Medicine

• Yoshida Tetsuya

  Department Of Chemistry Faculty Of Science Kumamoto University

• Yoshida Tetsuya

  Department Of Microbiology Hiroshima University School Of Medicine

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