In Vivo Metabolism of 5-Methoxy-N,N-diisopropyltryptamine in Rat
スポンサーリンク
概要
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The in vivo metabolism of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), a psychoactive tryptamine analog, was studied in rat. Male Wistar rats were administered 10 mg/kg 5-MeO-DIPT hydrochloride orally, and urinary fractions were collected. After enzymatic hydrolysis, the metabolites were extracted by liquid-liquid extraction and analyzed by gas chromatography/mass spectrometry. 5-Methoxy-N-isopropyltryptamine, 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT), 5-hydroxy-N-isopropyltryptamine, and 5-methoxyindole-3-acetic acid were identified as 5-MeO-DIPT metabolites. By quantitative analysis using high-performance liquid chromatography, it was revealed that 5-OH-DIPT was the main metabolite of 5-MeO-DIPT in rat, comprising 20.5% of the dose administered. On the other hand, only 0.8% of 5-MeO-DIPT administered was excreted into the urine in its original form.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
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Koike T
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Kuwayama Kenji
National Research Institute of Police Science
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Kanamori Tatsuyuki
National Research Institute of Police Science
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Iwata Yuko
National Research Institute of Police Science
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Inoue Hiroyuki
National Research Institute of Police Science
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Kuwayama Kenji
科学警察研究所
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KOIKE Tohru
Institute of Pharmaceutical Sciences Hiroshima University School of Medicine
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Kanamori Tatsuyuki
First Chemistry Section,National Research Institute of Police Science
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Tsujikawa Kenji
First Chemistry Section,National Research Institute of Police Science
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Iwata Yuko
First Chemistry Section,National Research Institute of Police Science
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Inoue Hiroyuki
First Chemistry Section,National Research Institute of Police Science
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Kishi Tohru
First Chemistry Section,National Research Institute of Police Science
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MIYAGUCHI Hajime
National Research Institute of Police Science
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Kuwayama Kenji
First Chemistry Section, National Research Institute of Police Science
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Miyaguchi Hajime
First Chemistry Section, National Research Institute of Police Science
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INOUE Hiroyuki
First Chemistry Section, National Research Institute of Police Science
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