Contribution of thermal desorption and liquid–liquid extraction for identification and profiling of impurities in methamphetamine by gas chromatography–mass spectrometry
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概要
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Impurity profiling of methamphetamine (MA) using thermal desorption (TD) and gas chromatography–mass spectrometry (GC–MS) was examined. Using TD/GC–MS, impurities were extracted and separated under various conditions. Optimal chromatograms were obtained when a 20 mg MA sample was extracted at 120 °C for 3 min using a TD instrument, followed by separation of the extracts using a non-polar capillary column coated with (5%phenyl)-methylpolysiloxane. MA samples from nine different batches were analyzed under optimized conditions. Compounds related to the structure of MA, such as benzaldehyde, benzyl alcohol, amphetamine, cis- and trans-1,2-dimethyl-3-phenylaziridine, dimethylamphetamine, and N-acetylephedrine, were detected in the chromatograms without any laborious extraction procedure. Compounds such as ethanol, diethyl ether, and acetic acid, which are considered reagents and solvents for MA synthesis, were also detected in some of the chromatograms. The numbers and intensities of the peaks detected were different among the samples. Impurity profiling of MA using TD was compared with that using liquid–liquid extraction (LLE). Better reproducibility of peak areas was obtained using LLE, whereas higher intensities and numbers of peaks were detected using TD. Solvents were extracted more effectively using TD. The nine batches of MA were classified using both extraction procedures. The nine batches were divided roughly into two groups using data from LLE. Subsequently, the groups were classified in detail using data from TD. TD can be used to provide supplemental information for LLE, and the combination of these extraction methods can be helpful for impurity profiling of MA.
- Elsevier Ireland Ltd.の論文
- 2007-08-24
著者
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水谷 忠士
Faculty Of Advanced Life Science Hokkaido University
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Koike T
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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水谷 忠士
Fac. Of Advanced Life Sci. Hokkaido Univ.
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Kuwayama Kenji
National Research Institute of Police Science
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Kanamori Tatsuyuki
National Research Institute of Police Science
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Iwata Yuko
National Research Institute of Police Science
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Inoue Hiroyuki
National Research Institute of Police Science
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Kuwayama Kenji
科学警察研究所
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Kamo Naoki
Faculty Of Advanced Life Science Hokkaido University
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Kamo Naoki
Laboratory Of Biophysical Chemistry Faculty Of Advanced Life Science Hokkaido University
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KOIKE Tohru
Institute of Pharmaceutical Sciences Hiroshima University School of Medicine
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Kamo Naoki
Faculty Of Pharmaceutical Sciences Grad. School Of Pharmaceutical Siences Hokkaido Univ.
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Kamo Naoki
College Of Pharmaceutical Science Matsuyama University Matsuyama Japan
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MIYAGUCHI Hajime
National Research Institute of Police Science
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