Excretory Profile of 4-Bromo-2,5-dimethoxy-phenethylamine (2C-B) in Rat
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概要
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The urinary and faecal metabolic profiles of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rat were investigated. Male Wistar rats were administrated 10 mg/kg of 2C-B hydrochloride orally, and the urine and faeces were collected 0-24 and 24-48 hr after administration. The samples were processed by liquid-liquid extraction, and the extracts analyzed by GC/MS, after derivatization. The major metabolite excreted into the urine was 5-O-desmethyl-N-acetyl-2C-B, comprising 13.2% of the administrated dose. Other metabolites detected in the urinary extracts were 2-O-desmethyl-N-acetyl-2C-B (5.8%), 2-O-desmethyl-2C-B (3.5%), carboxylic acid compound (1.9%), 5-O-desmethyl-2C-B (1.2%) and an alcoholic compound (0.8%). Only 0.2% of the administrated 2C-B was excreted into the urine in its original form. On the other hand, only 5-O-desmethyl-N-acetyl-2C-B and 2-O-desmethyl-N-acetyl-2C-B were detected in the faecal extracts. The major fraction of the urinary metabolites that contained a hydroxy group were recovered as conjugates.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
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Inouye Yoshio
School Of Pharmaceutical Sciences Toho University
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Koike T
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Kanamori Tatsuyuki
National Research Institute of Police Science
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Iwata Yuko
National Research Institute of Police Science
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Ohmae Yoshihito
National Research Institute of Police Science
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Inoue Hiroyuki
National Research Institute of Police Science
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KOIKE Tohru
Institute of Pharmaceutical Sciences Hiroshima University School of Medicine
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Inouye Yoshio
School Of Pharmaceutical Science Toho University
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Kanamori Tatsuyuki
First Chemistry Section,National Research Institute of Police Science
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Tsujikawa Kenji
First Chemistry Section,National Research Institute of Police Science
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Ohmae Yoshihito
First Chemistry Section,National Research Institute of Police Science
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Iwata Yuko
First Chemistry Section,National Research Institute of Police Science
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Inoue Hiroyuki
First Chemistry Section,National Research Institute of Police Science
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Kishi Tohru
First Chemistry Section,National Research Institute of Police Science
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INOUE Hiroyuki
First Chemistry Section, National Research Institute of Police Science
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