Mechanistic Considerations for the Consecutive Cyclization of 2,3-Dibromopropylamine Hydrobromide Giving a Strained Molecule, 1-Azabicyclo[1.1.0]butane

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概要

• 論文の詳細を見る

• The effective formation of 1-azabicyclo[1.1.0]butane (2) by treatment of 2,3-dibromopropylamine hydrobromide (1) with n-BuLi could be understood considering a rational reaction pathway via both transition states 10 and 19 based on the intramolecular Br…Li^+ coordination. A similar cyclization pathway starting from N-benzyl-3-bromopropylamine hydrochloride (17) to afford yV-benzylazetidine (18) could also be postulated on the basis of a transition state 20 involving the intramolecular Br…Li^+ coordination.

• 社団法人日本薬学会の論文
• 2004-01-01

著者

• SHIRO Motoo

  Rigaku Corporation X-ray Research Laboratory

• Shiro M

  Rigaku Corp. Tokyo

• IKEE Yoshifumi

  Graduate School of Pharmaceutical Sciences, The University of Tokushima

• HAYASHI Kazuhiko

  Faculity of Pharmaceutical Sciences, The University of Tokushima

• IKEE Yoshifumi

  Faculity of Pharmaceutical Sciences, The University of Tokushima

• GOTO Satoru

  Faculity of Pharmaceutical Sciences, The University of Tokushima

• NAGAO Yoshimitsu

  Faculity of Pharmaceutical Sciences, The University of Tokushima

• Hayashi Kyoko

  Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Ikee Yoshifumi

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 長尾 善光

  徳島大学薬学部

• Nagao Y

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Nagao Yoshimitsu

  Faculity Of Pharmaceutical Sciences The University Of Tokushima

• Shiro M

  Rigaku Corporation

• Goto S

  Faculity Of Pharmaceutical Sciences The University Of Tokushima

• Suzuki Mitsuko

  Institute For Chemical Research Kyoto University

• Masuoka S

  Takara Agri Co. Ltd.

• Nagao Y

  Faculty Of Agriculture Utsumomiya University

• Shiro Motoo

  Rigaku Co.

• Shiro Motoo

  Shionogi Research Laboratry Shionogi & Co. Ltd.

• Hayashi K

  Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama

• Mito S

  Institute For Chemical Research Kyoto University

• Shiro M

  Rigaku Corp. Akishima Jpn

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