Antiviral Targets of a Chromene Derivative from Sargassum micracanthum in the Replication of Human Cytomegalovirus(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
A chromene derivative (1) obtained from a brown alga, Sargassum micracanthum, has been proved to be a potent inhibitor of human cytomegalovirus (HCMV). In the present study, we evaluated its mode of action by various experimental assays. Time-of-addition experiments revealed that 1 was active if applied to cells before viral DNA synthesis, indicating that it inhibited early events of virus replication including virus adsorption and penetration, and a step immediately after viral internalization. Virus attachment and penetration studies suggested that one of the targets for anti-HCMV action of 1 was virus adsorption to cells and to a lesser extent, virus internalization was delayed in the presence of the compound. Pretreatment of virus particles with 1 showed that the compound exerted dose-dependent virucidal action. The chromene derivative and ganciclovir (GCV), an anti-HCMV drug, were synergistic inhibitors when used in combination. The synergistic effect could be explained by inhibition of different steps in HCMV replication cycle produced by 1 and GCV.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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Hayashi Kyoko
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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Hayashi Toshimitsu
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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SAITO Haruo
Department of Radiological Technology, School of Health Sciences, Faculty of Medicine
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Hayashi Kyoko
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Mori Jun
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Mori Jun
The Institute Of Scientific And Industrial Research Osaka University
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Saito H
Toyama Prefectural Institute For Pharmaceutical Research
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
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Hayashi T
Faculty Of Pharmaceutical Sciences Josai University
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Mori J
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Mori Jun
Department Of Pediatrics Kyoto Prefectural University Of Medicine
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Hayashi K
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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Saito Haruo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Hayashi Kyoko
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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MORI JUN
Department of Anesthesiology, Kurume University School of Medicine
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