Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
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概要
- 論文の詳細を見る
Signal transduction events which are involved in methyl jasmonate (MeJA)-enhanced production of the tetracyclic diterpene, scopadulcic acid B (SDB), were investigated in leaf organ cultures of Scoparia dulcis. Pretreatment of leaf organ cultures with Ca2+-channel blocker, verapamil, resulted in a dose-dependent inhibition of MeJA enhanced SDB production. Treatments with Ca2+ ionophore, A23187, stimulated SDB production in the absence of MeJA. In addition, preincubation of the leaf organ cultures with calmodulin (CaM) antagonist, trifluoperazine (TFP), diminished MeJA enhanced SDB production. MeJA-enhanced production of SDB was suppressed by addition of protein kinase inhibitors such as staurosporine and 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperdinyl]methyl)hexanamide (NPC-15437). An activator of protein kinase C, 1-oleoyl-2-acetyl-sn-glycerol (OAG), stimulated this production in the absence of MeJA. These results indicate that Ca2+ and CaM mediates signaling events leading to enhancement of SDB production upon MeJA treatment. It was also suggested that phosphorylation of protein by protein kinases might be involved in this signal pathway.
- 日本植物細胞分子生物学会の論文
- 2005-12-01
著者
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Lee Jung-bum
富山大学 大学院医学薬学研究部
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Lee Jung-bum
Faculty Of Pharmaceutical Sciences University Of Toyama
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Lee J‐b
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Sciences For Res.
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Hayashi Toshimitsu
Faculty Of Pharmaceutical Sciences University Of Toyama
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Hayashi Toshimitsu
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
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Hirooka Takashi
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
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NKEMBO Marguerite
Faculty of Pharmaceutical Sciences, University of Toyama
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Kurosaki Fumiya
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kurosaki Fumiya
Laboratory Of Plant Resource Sciences Graduate School Of Medicine And Pharmaceutical Science For Res
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Nkembo Marguerite
Faculty Of Pharmaceutical Sciences University Of Toyama
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