Evaluation of Scopadulciol-Related Molecules for Their Stimulatory Effect on the Cytotoxicity of Acyclovir and Ganciclovir against Herpes Simplex Virus Type 1 Thymidine Kinase Gene-Transfected HeLa Cells

スポンサーリンク

概要

• 論文の詳細を見る

• Herpes simplex virus type 1 thymidine kinase (HSV TK) is involved in both antiherpetic therapy and cancer gene therapy with acyclovir (ACV) and ganciclovir (GCV). Enhanced sensitivity to these drugs is advantageous in their clinical use. In the present study, scopadulciol (SDC) and its related compounds were evaluated for their stimulatory effect on the cytotoxicity of ACV and GCV by determination of selective toxicities against HSV TK-expressing HeLa cells. Although SDC remarkably potenciated the cytotoxicity of ACV and GCV, the other tested compounds showed only weak selectivity, except for compound 34.

• 公益社団法人日本薬学会の論文
• 2004-08-01

著者

• OHNO Hiroaki

  Graduate School of Pharmaceutical Sciences, Osaka University

• TANAKA Tetsuaki

  Graduate School of Pharmaceutical Sciences, Osaka University

• Ohno Hiroaki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Ohno Hiroaki

  Graduate School Of Pharmaceutical Sciences Osaka University

• Nemoto Hideo

  Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O

• Nemoto Hideo

  Faculty Of Pharmaceutical Sciences University Of Toyama

• Nemoto H

  Osaka City Univ. Osaka Jpn

• Rahman S.

  Graduate School Of Pharmaceutical Sciences Osaka University

• HAYASHI Toshimitsu

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Toyooka Naoki

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Hayashi K

  School Of Medicine Toyama Medical And Pharmaceutical University

• HAYASHI Kyoko

  School of Medicine, Toyama Medical and Pharmaceutical University

• Tanaka Tetsuaki

  Graduate School Of Pharmaceutical Sciences Of Osaka University

• Hayashi Toshimitsu

  Graduate School Of Medicine And Pharmaceutical Sciences For Res. Univ. Of Toyama

• Hayashi Toshimitsu

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Toyooka N

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Nemoto Hideo

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

関連論文

• Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus
• Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
• A Mouse Model of Sural Nerve Injury-Induced Neuropathy : Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
• Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice(Pharmacology)
• Central Administration of Neuropeptide B, But not Prolactin-Releasing Peptide, Stimulates Cortisol Secretion in Sheep
• Androgen Induces Production of Male Effect Pheromone in Female Goats
• The Effect of a Newly Synthesized Indazole Compound, TAS-3-124, on Experimental Autoimmune Disease(Pharmacology)
• Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists
• Psychosocial stress enhances IgE-mediated triphasic cutaneous reaction in mice : Antagonism by Yokukan-san (a Kampo medicine) and diazepam
• Effects of Shimotsu-to(a Kampo medicine, Si-Wu-Tang)and its constituents on triphasic skin reaction in passively sensitized mice.
• A Third-phase Cutaneous(Very Late Phase)Response after Elicitation with Dinitrofluorobenzene in Passively or Actively Sensitized Mice.
• Inhibitory Mechanisims of Glycoprotein Fraction Fraction Derived from Miscanthus Sinensis for the Immediate Phase Response of an IgE-mediated Cutaneous Reaction.
• Effect of Spikelets of Miscanthus Sinensis on IgE-Mediated Biphasic cutaneous Reaction in Mice.
• Evidence for Separate Involvement of Different μ-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids
• Pharmacological Evaluation of Morphine and Non-opioid Analgesic Adjuvants in a Mouse Model of Skin Cancer Pain(Pharmacology)
• Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice
• Repeated Treatment With the Traditional Medicine Unsei-in Inhibits Substance P-Induced Itch-Associated Responses Through Downregulation of the Expression of Nitric Oxide Synthase 1 in Mice
• Inhibitory Effect of the Repeated Treatment with Unsei-in on Substance P-Induced Itch-Associated Responses through the Downregulation of the Expression of NK_1 Tachykinin Receptor in Mice
• Inhibitory Effect of Azelastine on Allergic Itch-Associated Response in Mice Sensitized With Mosquito Salivary Glands Extract
• Stereodivergent Synthesis of Chiral 2-Alkenylaziridines : Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination
• P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists
• Geranylgeranyl Diphosphate Synthase from Scoparia dulcis and Croton sublyratus. Plastid Localization and Conversion to a Farnesyl Diphosphate Synthase by Mutagenesis
• Involvement of 2-C-Methyl-D-erythritol-4-phosphate Pathway in Biosynthesis of Aphidicolin-Like Tetracyclic Diterpene of Scoparia dulcis
• Helix Inducible Motifs Affect Helicity and Bioactivity of Anti-HIV Peptides
• The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice.
• Phenoxazine Derivatives Inactivate Human Cytomegalovirus, Herpes Simplex Virus-1, and Herpes Simplex Virus-2 In Vitro
• Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
• Total Synthesis of (±)-Stemodinone via an EfficientRing-Exchange Strategy
• Increase in respiratory resistance after exercise in conscious guinea pigs. : As a model for exercise-induced asthma.
• Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga Sargassum micracanthum, and a New Chromene Derivative Converted from the Plastoquinones(Pharmacognosy)
• Synthesis and Application of Novel Fluorescence-Labeled CXCR4 Antagonists
• Synthesis of Poison-Frog Alkaloids 237D, 207A, and Two Congeners of 235B' for Evaluation to Inhibitory Effect of Nicotinic Acetylcholine Receptors
• P-467 Structure-activity relationship study on GPR54 agonists
• Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
• Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
• Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
• STRUCTURE OF SCOPARIC ACID A, A NEW LABDANE-TYPE DITERPENOID FROM A PARAGUAYAN CRUDE DRUG "TYPYCHA KURATU" (SCOPARIA DULCIS L.)(Communications to the Editor)
• A third-phase cutaneous (very late phase) response after elicitation with dinitrofluorobenzene in passively or actively sensitized mice
• Roles of α-Adrenoceptors and Sympathetic Nerve in Acute Herpetic Pain Induced by Herpes Simplex Virus Inoculation in Mice
• Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain
• Time Course Study for Airway Inflammation and Responsiveness by Repeated Provocation of Aeroantigen in Guinea Pigs.
• Cysteinyl leukotrienes do not mediated lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs.
• Effect of a novel leukotoriene synthesis inhibitor, BAY x1005,on antigen- and LPS-induced airway hyperresponsiveness in guinea pigs.
• Relationship between hitamine release and leukotrienes production from human basophils derived from atopic dermatitis donors.
• Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models.
• Effects of NIP - 502 on Antigen - Induced Bronchial Responses and Allergic Reactions in Animal Models
• Studies on Anti-allergic Action of AH 21-132, a Novel Isozyme-Selective Phosphodiesterase Inhibitor in Airways
• Cloning and Expression of Calmodulin Gene in Scoparia dulcis(Pharmacognosy)
• Selective Enhancement of Scopadulcic Acid B Production in the Cultured Tissues of Scoparia dulcis by Methyl Jasmonate
• Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
• Effect of Am-80, a novel retinoid derivative, on contact hypersensitivity caused by repeated applications of hapten in mice
• Effects of Plastoquinones from the Brown Alga Sargassum micracanthum and a New Chromene Derivative Converted from the Plastoquinones on Acute Gastric Lesions in Rats(Pharmacognosy)
• New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum
• Evaluation of Scopadulciol-Related Molecules for Their Stimulatory Effect on the Cytotoxicity of Acyclovir and Ganciclovir against Herpes Simplex Virus Type 1 Thymidine Kinase Gene-Transfected HeLa Cells
• Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis
• Induction by carrageenan inflammation of prepronociceptin mRNA in VR1-immunoreactive neurons in rat dorsal root ganglia
• Pharmacological and Immunohistochemical Characterization of a Mouse Model of Acute Herpetic Pain
• Hepatocarcinogenic Activities of Hydorxymethyl Derivatives of 4-(N, N-Dimethylamino)azobenzene in ACI/N Rats.
• Synthesis and Anti-tumor Activity of a Fluorinated Analog of Medroxyprogesterone Acetate (MPA), 9α-Fluoromedroxyprogesterone Acetate (FMPA)
• Novel Antiviral Fucoidan from Sporophyll of Undaria pinnatifida (Mekabu)
• A Novel Antivirally Active Fucan Sulfate Derived from an Edible Brown Alga, Sargassum horneri
• Effects of Structural Modification of Calcium Spirulan, a Sulfated Polysaccharide from Spirulina Platensis, on Antiviral Activity
• An Antivirally Active Sulfated Polysaccharide from Sargassum horneri (TURNER) C.AGARDH
• Interleukin-1β Induces Interleukin-6 Production through the Production of Prostaglandin E_2in Human Osteoblast, MG-63 Cells.
• Geranylgeranyl Diphosphate Synthases from Scoparia dulcis and Croton sublyratus. cDNA Cloning, Functional Expression, and Conversion to a Farnesyl Diphosphate Synthase
• α-Bromo-α, α-difluoroallyl Derivatives as Synthetic Intermediate : Nucleophilic Substitution of α-Bromo-α, α-difluoroally Derivatives in the Presence of Palladium Catalysts
• Fluoroalkene Skeleton as a Peptide Bond Mimetic : Its Scope and Limitations
• A Novel Oxazolidine Linker for the Synthesis of Peptide Aldehydes
• Structure-Activity Relationship Studies on GPR54 Agonists
• Construction of Tricyclic Enone, a Common Precursor for Aphidicolane and Stemodane B/C/D-Ring System
• Marine Alkaloids (-)-Pictamine and (-)-Lepadin B Block Neuronal Nicotinic Acetylcholine Receptors(Pharmacology)
• P-206 SYNERGISTIC EFFECT OF OSELTAMIVIR AND ARCTIGENIN FROM SEEDS (GOBOSHI) OF ARCTIUM LAPPA L. ON ANTI-INFLUENZA A VIRUS ACTIVITY
• Identification of Novel HIV-1 Fusion Inhibitors by Template-Assisted Peptide Aldehyde Ligation
• Structure Activity Relationship Study of the Helix-inducible Motifs in HIV Fusion Inhibitors
• X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant
• Bioorganic Synthesis of End-capped HIV-1 Fusion Inhibitor SC35EK
• Seed Germination and Diterpenoid Production in Seedlings of Scoparia dulcis L
• Effect of Isoenzyme Selective Phosphodiesterase Inhibitors on Bacterial Lipopolysaccharide-induced Bronchial Hyperreactivity in Guinea Pigs.
• Participation of Leukotriene D4 and Tumor Necrosis Factor on Lipopolysaccharide-induced Airway Hyperresponsiveness in Guinea Pigs.
• Development of Novel GPR54 Agonists with Resistance to Degradation by MMP
• Diastereoselective Synthesis of (Z)-Fluoroalkene Dipeptide Isostere and the Application to a HIV Membrane Fusion Inhibitor
• Diastereoselective Synthesis of Trifluoromethylalkene Dipeptide Isosteres Based on Nucleophilic Trifluoromethylation
• P-132 Systematic Synthesis of THF-ring Cores and Total Synthesis of Antitumor Annonaceous Acetogenins
• The Effect of Mesoporphyrin on the Production of Cytokines by Inflammatory Cells In Vitro
• Suppressive Effects of Tranilast on Pulmonary Fibrosis and Activation of Alveolar Macrophages in Mice Treated with Bleomycin: Role of Alveolar Macrophages in the Fibrosis
• Development of Useful Reactions Involving Tandem Cyclizations Based on the Novel Reactivities of Allenic Compounds
• Effects of Brief Exposure of Male Pheromone on Multiple-Unit Activity at Close Proximity to Kisspeptin Neurons in the Goat Arcuate Nucleus
• Stereoselective Synthesis of Tyr-Orn Type Alkene Dipeptide Isosteres and Their Application to Bioactive Peptides
• The role of thromboxane A_2 in experimental liver injury in mice.
• Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
• Functional Characterization of Kisspeptin Receptor Ligands : Activation of Neuropeptide FF Receptors
• Participation of Leukotriene D_4 and Tumor Necrosis Factor on Lipopolysaccharide-Induced Airway Hyperresponsiveness in Guinea Pigs
• Change in the Activity of the Cyclic AMP-Dependent Protein Kinase in Antigen-Stimulated Sensitized Mast Cells and Effect of Drugs Inhibiting Allergic Mediator Release.
• Synthetic Studies on Coibamide A
• Seed Germination and Diterpenoid Production in Seedlings of Scoparia dulcis L.
• Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
• Chemical and Pharmaceutical Studies on Medicinal Plants in Paraguay : Constituents of Angiotensin Converting Enzyme Inhibitory Fraction from "Cocu," Allophylus edulis RADLK
• Enhanced Plasmid DNA Transfer into Tumor Cells by Nanoparticle Composed of Cholesteryl Triamine and Diamine
• Synthetic Organic Chemistry Based on Small Ring Compounds
• Synthesis and Investigation of Novel Metal Complexes of Deferriferrichrysin

もっと見る 閉じる

スポンサーリンク