X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant
スポンサーリンク
概要
- 論文の詳細を見る
- 2009-03-01
著者
-
Nakano Hiroaki
Graduate School of Science and Engineering, Chuo University
-
Nakashima H
Graduate School Of Pharmaceutical Sciences Kyoto University
-
MATSUOKA Masao
Laboratory of Virus Control, Institute for Virus Research, Kyoto University
-
OHNO Hiroaki
Graduate School of Pharmaceutical Sciences, Osaka University
-
FUJII Nobutaka
Graduate School of Pharmaceutical Sciences, Kyoto University
-
OISHI Shinya
Graduate School of Pharmaceutical Sciences, Kyoto University
-
MATSUOKA Masao
Institute for Virus Research, Kyoto University
-
Oishi S
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Oishi Shinya
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Oishi Shinya
Laboratory Of Medicinal Chemistry Ccr Nci Nih
-
Okamura H
Laboratory Of Neurobiology National Institute Of Agrobiological Sciences
-
Ohno Hiroaki
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Matsuoka Masao
Institute For Virus Research Kyoto University
-
Matsuoka Masao
Laboratory For Virus Immunology Institute For Virus Research Kyoto University
-
Nakano Hiroaki
Graduate School Of Pharmaceutical Sciences Osaka University
-
WATANABE Kentaro
Graduate School of Pharmaceutical Sciences, Kyoto University
-
IZUMI Kazuki
Institute for Virus Research, Kyoto University
-
KODAMA Eiichi
Laboratory of Virus Immunology, Research Center for Acquired Immune Deficiency Syndrome, Institute f
-
Fujii N
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Fujii Nobutaka
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Fujii Nobutaka
Department Of Pharmaceutical Manufacturing Graduate School Of Pharmaceutical Science Kyoto Universit
-
Nakashima Hideki
Department Of Microbiology And Immunology Kagoshima University Dental School
-
Nakano Hiroaki
Departmetnt Of Pharmacy Hyogo University Of Health Sciences
-
Nakatsu Toru
Graduate School of Pharmaceutical Sciences, Kyoto University
-
Kato Hiroaki
Graduate School of Pharmaceutical Sciences, Kyoto University
-
Nakashima Hideki
Department Of Microbiology St. Marianna University School Of Medicine
-
Izumi Kazuki
Institute For Virus Research Kyoto University
-
Mizumoto Makiko
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Watanabe Kunihiko
Division Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Kyoto Prefectur
-
WATABE Tsuyoshi
Graduate School of Pharmaceutical Sciences, Kyoto University
-
IZUMI Kazuki
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University
-
Watabe Tsuyoshi
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Kato Hiroaki
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Nakatsu Toru
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Nakashima H
Departmetnt Of Pharmacy Hyogo University Of Health Sciences
-
Nishikawa Hiroki
Departmetnt Of Pharmacy Hyogo University Of Health Sciences
-
Watanabe Kentaro
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Kamitani Hirotaka
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Kato Hiroaki
Graduate School Of Bioagricultural Sciences Nagoya University
-
Nishikawa Hiroki
Graduate School Of Pharmaceutical Sciences Kyoto University
関連論文
- HTLV-1 and the Host Immune System : How the Virus Disrupts Immune Regulation, Leading to HTLV-1 Associated Diseases
- Development of Quasi-Monoenergetic Neutron Source Using the 1H(13C,n) Reaction
- Central Administration of Neuropeptide B, But not Prolactin-Releasing Peptide, Stimulates Cortisol Secretion in Sheep
- Androgen Induces Production of Male Effect Pheromone in Female Goats
- HTLV-1 and the Host Immune System : How the Virus Disrupts Immune Regulation, Leading to HTLV-1 Associated Diseases
- AN ADAPTIVE SUBDIVISION OF BEAMS FOR POLYGONAL OBJECTS IN VISUAL SIMULATION OF HIGH FREQUENCY ELECTROMAGNETIC WAVE PROPAGATION(International Workshop on Advanced Image Technology 2007)
- NMR Studies on Structure and Action Mechanism of Sulfated Dodecyl Laminaripentaoside with High Anti-Human Immunodeficiency Virus Activity
- Synthesis of Azidothymidine-Bound Sulfated Alkyl Oligosaccharides and Their Inhibitory Effects on AIDS Virus Infection In Vitro
- Synthesis of Azidothymidine-Bound Curdlan Sulfate with Anti-Human Immunodeficiency Virus Activity in Vitro
- アセタミド基含有硫酸化多糖の合成と抗HIV活性
- Stereodivergent Synthesis of Chiral 2-Alkenylaziridines : Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination
- Synthesis of a CC Chemokine, vMIP-II, Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Its Biological Activity
- Structure and Function of Domain I of Ribosome Recycling Factor
- 1P011 コラーゲン分解酵素Pz-Aの立体構造と機能(蛋白質-構造,第48回日本生物物理学会年会)
- Development of Chemical Probes for the Chemokine Receptor CXCR4 Involving Radiolabeled T140 Analogs
- Development of the Chemokine Receptor CXCR4 Antagonists as Multi-Pharmaceutical Agents Involving a New Class of Low Molecular Weight Antagonists
- P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists
- Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
- The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
- New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
- A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
- CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
- Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
- Development of Specific CXCR4 Inhibitors Based on an Anti-HIV Peptide, T140, and Their Structure-Activity Relationships Study
- Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1
- Sulfated Fibroin, a Novel Sulfated Peptide Derived from Silk, Inhibits Human Immunodeficiency Virus Replication in Vitro
- HIV-cell Fusion Inhibitors Targeted to the HIV Second Receptor : T22 and Its Downsized Analogs with High Activity
- Design, Synthesis and Activity of Shortened Analogs of an Anti-HIV Peptide, T22
- Helix Inducible Motifs Affect Helicity and Bioactivity of Anti-HIV Peptides
- Synthesis of Sulfated Deoxy-Ribofuranans Having Selective Anti-AIDS Virus Activity by Ring-Opening Copolymerization of 1,4-Anhydro Ribose Derivatives
- Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity
- STRUCTURE-ACTIVITY RELATIONSHIPS OF TACHYPLESIN ANALOGS AS ANTI-HIV AGENT
- STRUCTURES AND ACTIVITIES OF TANNINS IN CRUDE DRUGS (4) : EFFECTS ON PHAGOCYTES AND VIRUSES
- Synthesis of CXCR4 Antagonists, T140 Derivatives with Improved Biostability, and Their SAR Study
- Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion
- Application of β-Branched Allylglycine Equivalents to Macrocyclic Grb2 SH2 Domain-Binding Inhibitors
- Total Synthesis of (±)-Stemodinone via an EfficientRing-Exchange Strategy
- Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isostere and Its Biological Activity
- Synthesis and Application of Novel Fluorescence-Labeled CXCR4 Antagonists
- Design and Synthesis of Highly Active Anti-HIV Peptide Based on Gp41-C34 Peptide
- P-467 Structure-activity relationship study on GPR54 agonists
- Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
- Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
- Synthesis of (Z)-Alkene cis-Ala-Pro Mimetics Using Organocopper Reagents
- Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
- Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
- Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
- Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
- Properties of Intracellular Fragment Peptides of Mouse Prostaglandin E_2 Receptor EP3 Isoform
- Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus(Virology)
- Synthetic Studies of Tokaramide A and Miraziridine A Isolated from Marine Sponge Theonella aff. mirabilis
- P-39 2'-DEXY-4'-C-ETHYNYL-2-FLUOROADENOSINE, A NRTI THAT COULD BE AN IDEAL DRUG FOR BOTH HIV-AND HBV-INFECTIONS
- Evaluation of Scopadulciol-Related Molecules for Their Stimulatory Effect on the Cytotoxicity of Acyclovir and Ganciclovir against Herpes Simplex Virus Type 1 Thymidine Kinase Gene-Transfected HeLa Cells
- Implication of the HTLV-I bZIP Factor Gene in the Leukemogenesis of Adult T-Cell Leukemia
- Specific Fluorescence Labeling of Membrane Receptors in Living Cells using Coiled-coil Tag
- Fluoroalkene Skeleton as a Peptide Bond Mimetic : Its Scope and Limitations
- Establishment and Clinical Application of an Enzyme Immunoassay for Metastin to Determination of the Human Plasma Levels
- A Novel Oxazolidine Linker for the Synthesis of Peptide Aldehydes
- Structure-Activity Relationship Studies on GPR54 Agonists
- Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
- Cyclic Analogs Derived from Laminin Enhanced the Biological Activities
- Biological Activity of a Cyclic Peptide from Laminin α1 Chain Loop Region
- Synthesis and Application of Novel Phosphotyrosyl Mimetics to Grb2 SH2 Domain-Binding Inhibitors
- Construction of Tricyclic Enone, a Common Precursor for Aphidicolane and Stemodane B/C/D-Ring System
- Synthesis of (Z)-Alkene cis-Xaa-Pro Type Dipeptide Isosteres Using Organocopper-Mediated Anti-S_N2' Reactions
- 4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
- Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α, β-enoates and Their Application
- In Vitro Anti-Human Immunodeficiency Virus Activity of Polysaccharide from Rhizophora mucronata Poir.
- Mangrove Halophytes: A source of antiviral substances
- Structure-Activity Relationship Study of CXCR4 Antagonists on the Cyclic Pentapeptide Scaffold : Identification of New Pharmacophore Moieties
- Leukemogenesis of Adult T-Cell Leukemia
- Ars Insulator Identified in Sea Urchin Possesses an Activity to Ensure the Transgene Expression in Mouse Cells
- Oligoarginine-mediated Delivery of Bioactive Peptides into Living cells
- Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biologically Active Peptide. Part 1
- Identification of Novel HIV-1 Fusion Inhibitors by Template-Assisted Peptide Aldehyde Ligation
- Structure Activity Relationship Study of the Helix-inducible Motifs in HIV Fusion Inhibitors
- X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant
- Bioorganic Synthesis of End-capped HIV-1 Fusion Inhibitor SC35EK
- Stereoselective Synthesis of CF_2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptides
- Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
- Interactions between Local Anesthetics and Na^+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by ^1H-NMR Spectroscopy
- SOMATIC ALTERATIONS IN ADULT T-CELL LEUKEMIA CELLS
- Translocation of Basic Peptides through Human Cell Membranes
- Development of Novel GPR54 Agonists with Resistance to Degradation by MMP
- Diastereoselective Synthesis of (Z)-Fluoroalkene Dipeptide Isostere and the Application to a HIV Membrane Fusion Inhibitor
- Diastereoselective Synthesis of Trifluoromethylalkene Dipeptide Isosteres Based on Nucleophilic Trifluoromethylation
- Synthesis of Peptide Thioester Based on N-S Acyl Transfer Utilizing Cysteine-derived Acyloxazolidinone with Practical Application to Peptide Synthesis
- New Strategy for The Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement"
- Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
- Utility of Plasma Bioactive Peptides Levels as Biomarkers
- Synthesis of (E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents
- Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Dipeptide Isosteres Utilizing Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions
- Development of Useful Reactions Involving Tandem Cyclizations Based on the Novel Reactivities of Allenic Compounds
- Stereoselective Synthesis of Tyr-Orn Type Alkene Dipeptide Isosteres and Their Application to Bioactive Peptides
- Functional Characterization of Kisspeptin Receptor Ligands : Activation of Neuropeptide FF Receptors
- Synthetic Studies on Coibamide A
- High-Throughput Turbidimetric Screening for Heparin-Neutralizing Agents and Low-Molecular-Weight Heparin Mimetics
- Chronic Peripheral Administration of Kappa-Opioid Receptor Antagonist Advances Puberty Onset Associated with Acceleration of Pulsatile Luteinizing Hormone Secretion in Female Rats
- Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows
- Synthesis and Investigation of Novel Metal Complexes of Deferriferrichrysin