Sulfated Fibroin, a Novel Sulfated Peptide Derived from Silk, Inhibits Human Immunodeficiency Virus Replication in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
We prepared two kinds of sulfated silk fibroins, SclFib30 and SclFib31,which contain different amounts of sulfate. These sulfated silk fibroins have anti-HIV-1 activity in vitro, apparently due to CD4^+ cells, and completely blocked virus binding to the cells at a concentration of 100 μg/ml. Sulfated fibroins also abolished cell-to-cell infection-induced syncytium formation upon cocultivation of MOLT-4 and MOLT-4/HIV-1_<IIIB> cells, suggesting that they would interfere with gp120 and prevent the formation of gp120/CD4 complex. Silk is used in biomaterials such as surgical sutures and is believed to be a safe material for humans. In accordance with low anticoagulant activity and high anti-HIV-1 activity against both X4 HIV-1 and R5 HIV-1 strains, sulfated silk fibroins have potential as antiviral material such for a vaginal anti-HIV formulation.
- 社団法人日本農芸化学会の論文
- 2000-08-23
著者
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Nakashima Hideki
Department of Microbiology and Immunologu,Kagoshima University Dental School
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Gotoh Kazuyo
Department of Microbiologyand Immunologu, Kagoshima University Dental School
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Kanamoto Taisei
Department of Dental Pharmacology,Meikai University School of Dentistry
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IZUMI Hiroyuki
Department of Ergonomics, Institute of Industrial Ecological Sciences, University of Occupational an
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Nakashima H
Graduate School Of Pharmaceutical Sciences Kyoto University
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TAMADA Yasushi
Biomimetics Laboratory, National Institute of Sericultural and Entomological Science
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Gotoh Kazuyo
Department Of Microbiology And Immunology Kagoshima University Dental School
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Gotoh Kazuyo
Department Of Infectious Diseases Faculty Of Medicine Oita University
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Izumi H
Department Of Materials Science Tokai University
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Tamada Yasushi
Biomimetics Laboratory National Institute Of Sericultural And Entomological Science
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Nakashima H
St. Marianna University School Of Medicine
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Kanamoto T
Department Of Microbiology And Immunology Kagoshima University Dental School
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Nakashima Hideki
Department Of Microbiology And Immunology Kagoshima University Dental School
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Nakano Hiroaki
Departmetnt Of Pharmacy Hyogo University Of Health Sciences
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Nakashima Hideki
Department Of Microbiology St. Marianna University School Of Medicine
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Nakashima Hideki
Department Of Advanced Energy Engineering Science Interdisciplinary Graduate School Of Engineering S
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Nakashima Hideki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Izumi Hiroyuki
Department Of Microbiology And Immunology Kagoshima University Dental School:shin Nippon Biomedical
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Nakashima H
Departmetnt Of Pharmacy Hyogo University Of Health Sciences
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Nishikawa Hiroki
Departmetnt Of Pharmacy Hyogo University Of Health Sciences
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Izumi Hiroyuki
Department Of Chemistry Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Nishikawa Hiroki
Graduate School Of Pharmaceutical Sciences Kyoto University
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