Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study

スポンサーリンク

概要

• 論文の詳細を見る
• 2002-03-01

著者

• 大高 章

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Nakashima H

  Graduate School Of Pharmaceutical Sciences Kyoto University

• FUJII Nobutaka

  Graduate School of Pharmaceutical Sciences, Kyoto University

• XU Younong

  Institute for Virus Research, Kyoto University

• TAMAMURA Hirokazu

  Graduate School of Pharmaceutical Sciences, Kyoto University

• OTAKA akira

  Graduate School of Pharmaceutical Sciences, Kyoto University

• HIRAMATSU Kenichi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• NAKASHIMA Hideki

  St. Marianna University, School of Medicine

• OMAGARI Akane

  Graduate School of Pharmaceutical Sciences, Kyoto University

• MATSUOKA Masao

  Institute for Virus Research, Kyoto University

• Xu Younong

  Institute For Virus Research Kyoto University

• Otaka Akira

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Otaka Akira

  Institute Of Health Biosciences Graduate School Of Pharmaceutical Sciences The University Of Tokushi

• Omagari Akane

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Matsuoka Masao

  Institute For Virus Research Kyoto University

• Nakashima H

  St. Marianna University School Of Medicine

• Fujii N

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Fujii Nobutaka

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Tamamura H

  Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University

• Tamamura Hirokazu

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Nakashima Hideki

  St. Marianna University School Of Medicine

• Nakashima Hideki

  Department Of Microbiology And Immunology Kagoshima University Dental School

• Hiramatsu Kenichi

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Nakano Hiroaki

  Departmetnt Of Pharmacy Hyogo University Of Health Sciences

• Nakashima Hideki

  Department Of Microbiology St. Marianna University School Of Medicine

• Nakashima Hideki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Mizumoto Makiko

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Nakashima H

  Departmetnt Of Pharmacy Hyogo University Of Health Sciences

• Nishikawa Hiroki

  Departmetnt Of Pharmacy Hyogo University Of Health Sciences

• Otaka Akira

  Univ. Tokushima Tokushima Jpn

• Nishikawa Hiroki

  Graduate School Of Pharmaceutical Sciences Kyoto University

関連論文

• Development of Quasi-Monoenergetic Neutron Source Using the 1H(13C,n) Reaction
• NMR Studies on Structure and Action Mechanism of Sulfated Dodecyl Laminaripentaoside with High Anti-Human Immunodeficiency Virus Activity
• Synthesis of Azidothymidine-Bound Sulfated Alkyl Oligosaccharides and Their Inhibitory Effects on AIDS Virus Infection In Vitro
• Synthesis of Azidothymidine-Bound Curdlan Sulfate with Anti-Human Immunodeficiency Virus Activity in Vitro
• アセタミド基含有硫酸化多糖の合成と抗HIV活性
• Stereodivergent Synthesis of Chiral 2-Alkenylaziridines : Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination
• Synthesis of a CC Chemokine, vMIP-II, Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Its Biological Activity
• 1P011 コラーゲン分解酵素Pz-Aの立体構造と機能(蛋白質-構造,第48回日本生物物理学会年会)
• Development of Chemical Probes for the Chemokine Receptor CXCR4 Involving Radiolabeled T140 Analogs
• Development of the Chemokine Receptor CXCR4 Antagonists as Multi-Pharmaceutical Agents Involving a New Class of Low Molecular Weight Antagonists
• P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists
• Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
• The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
• New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
• A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
• CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
• Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
• Development of Specific CXCR4 Inhibitors Based on an Anti-HIV Peptide, T140, and Their Structure-Activity Relationships Study
• Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1
• Sulfated Fibroin, a Novel Sulfated Peptide Derived from Silk, Inhibits Human Immunodeficiency Virus Replication in Vitro
• HIV-cell Fusion Inhibitors Targeted to the HIV Second Receptor : T22 and Its Downsized Analogs with High Activity
• Design, Synthesis and Activity of Shortened Analogs of an Anti-HIV Peptide, T22
• リン酸化ペプチドの化学合成 (構造生物学のフロンティア--シグナル伝達とDNAトランスアクション) -- (構造生物学の方法論の新しい展開)
• Helix Inducible Motifs Affect Helicity and Bioactivity of Anti-HIV Peptides
• Synthesis of Sulfated Deoxy-Ribofuranans Having Selective Anti-AIDS Virus Activity by Ring-Opening Copolymerization of 1,4-Anhydro Ribose Derivatives
• Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity
• STRUCTURE-ACTIVITY RELATIONSHIPS OF TACHYPLESIN ANALOGS AS ANTI-HIV AGENT
• STRUCTURES AND ACTIVITIES OF TANNINS IN CRUDE DRUGS (4) : EFFECTS ON PHAGOCYTES AND VIRUSES
• Synthesis of CXCR4 Antagonists, T140 Derivatives with Improved Biostability, and Their SAR Study
• Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion
• Development of Stimulus-Responsive Amino Acid with Peptide Bond-Cleavage Ability and Its Application to a Nucleocytoplasmic Shuttle Peptide
• Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isostere and Its Biological Activity
• Synthesis and Application of Novel Fluorescence-Labeled CXCR4 Antagonists
• Design and Synthesis of Highly Active Anti-HIV Peptide Based on Gp41-C34 Peptide
• P-467 Structure-activity relationship study on GPR54 agonists
• Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
• Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
• Synthesis of (Z)-Alkene cis-Ala-Pro Mimetics Using Organocopper Reagents
• Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
• Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
• Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
• Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
• Properties of Intracellular Fragment Peptides of Mouse Prostaglandin E_2 Receptor EP3 Isoform
• Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus(Virology)
• Synthetic Studies of Tokaramide A and Miraziridine A Isolated from Marine Sponge Theonella aff. mirabilis
• P-39 2'-DEXY-4'-C-ETHYNYL-2-FLUOROADENOSINE, A NRTI THAT COULD BE AN IDEAL DRUG FOR BOTH HIV-AND HBV-INFECTIONS
• A New Practical Strategy for the Synthesis of Long-Chain Phosphopeptide
• Synthesis of Nonhydrolyzable Phosphothreonine Derivatives and Their Practical Application to Peptide Synthesis
• Specific Fluorescence Labeling of Membrane Receptors in Living Cells using Coiled-coil Tag
• Identification of Biologically Active Peptides in Laminin-1
• Fluoroalkene Skeleton as a Peptide Bond Mimetic : Its Scope and Limitations
• A Novel Oxazolidine Linker for the Synthesis of Peptide Aldehydes
• Structure-Activity Relationship Studies on GPR54 Agonists
• Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
• Biological Activity of a Cyclic Peptide from Laminin α1 Chain Loop Region
• HSP47-Binding Structural Epitopes in Triple Helical Collagen
• Synthesis of (Z)-Alkene cis-Xaa-Pro Type Dipeptide Isosteres Using Organocopper-Mediated Anti-S_N2' Reactions
• 4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
• Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α, β-enoates and Their Application
• Solid Phase Synthesis of α-N- and Side-Chain O-Fully Sulfated Homooligomers of Tyrosine
• In Vitro Anti-Human Immunodeficiency Virus Activity of Polysaccharide from Rhizophora mucronata Poir.
• Mangrove Halophytes: A source of antiviral substances
• Structure-Activity Relationship Study of CXCR4 Antagonists on the Cyclic Pentapeptide Scaffold : Identification of New Pharmacophore Moieties
• Leukemogenesis of Adult T-Cell Leukemia
• Oligoarginine-mediated Delivery of Bioactive Peptides into Living cells
• Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biologically Active Peptide. Part 1
• Identification of Novel HIV-1 Fusion Inhibitors by Template-Assisted Peptide Aldehyde Ligation
• Structure Activity Relationship Study of the Helix-inducible Motifs in HIV Fusion Inhibitors
• X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant
• Bioorganic Synthesis of End-capped HIV-1 Fusion Inhibitor SC35EK
• Stereoselective Synthesis of CF_2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptides
• Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
• Synthesis of Peptide Thioesters using N-Substituted Aniline Derivatives
• Efficient Induction of Pptide - Specific Cytotoxic T Lymphocytes by LPS - Activated Spleen Cells
• Interactions between Local Anesthetics and Na^+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by ^1H-NMR Spectroscopy
• SOMATIC ALTERATIONS IN ADULT T-CELL LEUKEMIA CELLS
• Translocation of Basic Peptides through Human Cell Membranes
• Development of Novel GPR54 Agonists with Resistance to Degradation by MMP
• Diastereoselective Synthesis of (Z)-Fluoroalkene Dipeptide Isostere and the Application to a HIV Membrane Fusion Inhibitor
• Diastereoselective Synthesis of Trifluoromethylalkene Dipeptide Isosteres Based on Nucleophilic Trifluoromethylation
• Synthesis of Peptide Thioester Based on N-S Acyl Transfer Utilizing Cysteine-derived Acyloxazolidinone with Practical Application to Peptide Synthesis
• New Strategy for The Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement"
• Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
• Utility of Plasma Bioactive Peptides Levels as Biomarkers
• Synthesis of (E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents
• Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Dipeptide Isosteres Utilizing Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions
• Influence of an Amino Acid Sequence on Kinetics of Peptide Bond Cleavage Reaction Induced by a Stimulus-responsive Amino Acid
• Application of Peptide Thioacids to NCL-type Sequential Condensation of Peptide Fragments
• Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere
• Development of Stimulus Responsive Thiol Releasing System for Controlling Activity of Cysteine Protease
• P-202 DEVELOPMENT OF PHOTO-TRIGGERED SELF-PROCESSING PEPTIDES
• Synthesis of Nonhydrolyzable AMPylated Amino Acid Analogues for Uncovering the Physiological Role of AMPylation
• Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins
• Native Chemical Ligation Using N-peptidyl Anilide as Crypto-thioester
• Enantioselective Synthesis of Stimulus-responsive Amino Acid via Pyrrolidinyl Tetrazole Catalyzed Asymmetric α-Amination of Aldehyde
• Synthesis and Biological Evaluation of CXCL14 and Its Derivatives
• Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organocopper or SmI_2 Reagents
• Caged Ceramide Which Releases Parent Ceramide After UV-Induced Amide Bond Cleavage Followed by Intramolecular O-N Acyl Transfer
• Double-Kinetically Controlled Proline Ligation
• N-Sulfanylethylanilide Peptide : A Peptide Thioester Equivalent Which Can Directly Participate in Native Chemical Ligation

もっと見る 閉じる

スポンサーリンク