Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
スポンサーリンク
概要
- 論文の詳細を見る
- 2005-03-01
著者
-
大高 章
Graduate School Of Pharmaceutical Sciences The University Of Tokushima
-
束村 博子
名古屋大学 大学院生命農学研究科生殖科学研究分野
-
束村 博子
名古屋大学大学院生命農学研究科生命技術科学専攻
-
FUJII Nobutaka
Graduate School of Pharmaceutical Sciences, Kyoto University
-
OISHI Shinya
Graduate School of Pharmaceutical Sciences, Kyoto University
-
TAMAMURA Hirokazu
Graduate School of Pharmaceutical Sciences, Kyoto University
-
OTAKA akira
Graduate School of Pharmaceutical Sciences, Kyoto University
-
ARAKI Takanobu
Graduate School of Pharmaceutical Sciences, Kyoto University
-
UEDA Satoshi
Graduate School of Pharmaceutical Sciences, Kyoto University
-
WANG Zixuan
Medical College of Georgia
-
PEIPER Stephen
Medical College of Georgia
-
Peiper Stephen
Department of Pathology, Medical College of Georgia
-
ESAKA Ai
Graduate School of Pharmaceutical Sciences, Kyoto University
-
Wang Zi-xuan
Medical College Of Georgia
-
Peiper Stephen
Department Of Pathology Medical College Of Georgia
-
Otaka Akira
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Otaka Akira
Institute Of Health Biosciences Graduate School Of Pharmaceutical Sciences The University Of Tokushi
-
Oishi S
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Oishi Shinya
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Oishi Shinya
Laboratory Of Medicinal Chemistry Ccr Nci Nih
-
Omagari Akane
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Fujii N
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Fujii Nobutaka
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Tamamura H
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
-
Tamamura Hirokazu
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Tamamura Hirokazu
Faculty Of Pharmaceutical Sciences Kyoto University
-
Araki Takanobu
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Esaka Ai
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Ueda Satoshi
Graduate School Of Engineering University Of Hyogo
-
Otaka Akira
Univ. Tokushima Tokushima Jpn
関連論文
- 生殖を司る神経ペプチド、メタスチン/キスペプチン
- メタスチン/キスペプチン-種を超えて生殖を司る神経ペプチド : GnRHの上位にあって性腺刺激ホルモン分泌をコントロールする
- Quantitative Analysis of mRNA for 10 Different Drug Resistance Factors in Dogs with Lymphoma
- 妊娠期, 授乳期1-ブロモプロパン曝露による母・仔ラットへの影響
- 11.妊娠期・授乳期1-ブロモプロパン曝露による, 母・仔ラットへの影響(一般演題)(第32回有機溶剤中毒研究会)
- 1-ブロモプロパン曝露はラット卵巣における卵胞発達を阻害す
- Food Deprivation Induces Monocarboxylate Transporter 2 Expression in the Brainstem of Female Rat
- Acute Lipoprivation Suppresses Pulsatile Luteinizing Hormone Secretion without Affecting Food Intake in Female Rats
- エストロゲンと視床下部--フィードバック機構の鍵を握るメタスチン/キスペプチンニューロンの役割 (特集 性ステロイドホルモンの作用)
- キスペプチン(メタスチン)による繁殖機能制御とその応用 (あゆみ 生理活性ペプチド研究の新展開--機能解析から治療応用まで)
- 雌ラットの黄体形成ホルモンサージおよび発情周期におけるメタスチンの生理的役割
- メタスチン metastin (キスペプチン kisspeptin)とGnRH分泌
- メタスチン(キスペプチン) : 生殖機能を制御する神経ペプチド
- 生理的GnRH放出因子,メタスチン(キスペプチン)の基礎と応用
- メタスチン (特集 中枢内分泌の最新知見とその異常)
- 繁殖機能を制御するエネルギーセンサーとその応用の可能性 (特集 家畜における栄養と繁殖機能についての最前線)
- メタスチン(キスペプチン)--生殖機能を制御する神経ペプチド (特集 新しいGPCRリガンド研究の現状と展望)
- 排卵と性行動を制御する脳の性分化
- 雌ラットのパルス状黄体形成ホルモン分泌調節における分界条床核のアドレナリン受容体の役割
- グルコース利用阻害による視床下部室傍核と延髄での Fos タンパクの発現
- 絶食による視床下部および延髄孤束核での c-Fos タンパクの発現について : 特にカテコールアミンとテストステロンの役割
- Potencies of Centrally- or Peripherally-Injected Full-Length Kisspeptin or Its C-Terminal Decapeptide on LH Release in Intact Male Rats
- Paraventricular α1- and α2-Adrenergic Receptors Mediate Hindbrain Lipoprivation-induced Suppression of Luteinizing Hormone Pulses in Female Rats
- Neuroendocrine mechanism mediating energetic regulation of gonadotropin release in female rats
- Kisspeptin/metastinと生殖機能制御 (内分泌) -- (基礎分野での進歩)
- 視床下部-下垂体-性腺軸のマスターレギュレーターとしてのメタスチン(キスペプチン) (特集 視床下部・下垂体領域の最近の話題) -- (病態生理の解明)
- パネルディスカッション 男女共同参画の明るい未来に向けて (特集 学術分野における男女共同参画促進のために)
- Development of Chemical Probes for the Chemokine Receptor CXCR4 Involving Radiolabeled T140 Analogs
- Development of the Chemokine Receptor CXCR4 Antagonists as Multi-Pharmaceutical Agents Involving a New Class of Low Molecular Weight Antagonists
- P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists
- Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
- The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
- New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
- A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
- CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
- Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
- Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase
- Development of Peptide Tools for Fluorescence Imaging of Proteins in Living Cells
- Development of Stimulus-Responsive Amino Acid with Peptide Bond-Cleavage Ability and Its Application to a Nucleocytoplasmic Shuttle Peptide
- Internal medicine: Gastrointestinal and hematologic adverse events after administration of vincristine, cyclophosphamide, and doxorubicin in dogs with lymphoma that underwent a combination multidrug chemotherapy protocol
- Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
- Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
- Synthesis of (Z)-Alkene cis-Ala-Pro Mimetics Using Organocopper Reagents
- Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
- Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
- Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
- Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
- Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus(Virology)
- 名古屋大学における男女共同参画推進の取組み(男女共同参画のページ)
- Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
- Synthesis of (Z)-Alkene cis-Xaa-Pro Type Dipeptide Isosteres Using Organocopper-Mediated Anti-S_N2' Reactions
- 4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
- Development of Inhibitory Peptides against HIV-1 Integrase
- Structure-Activity Relationship Study of CXCR4 Antagonists on the Cyclic Pentapeptide Scaffold : Identification of New Pharmacophore Moieties
- Development of Fluorescent Labeled CXCR4 Specific Ligand for Imaging and Fluorescence-Based Screening
- Small-Sized CD4 Mimics Targeted for Dynamic Supramolecular Mechanism of HIV-1 Entry
- Fluorescent Labeling for PKC delta C1b Domain and Its Application to Sensing Biology
- Development of Caged Diacylglycerol-Lactone Derivatives and Their Applications
- Development of a Novel Tag-Probe System for Fluorescent Imaging of Proteins in Living Cells
- Simultaneous Observation of the GnRH Pulse Generator Activity and Plasma Concentrations of Metabolites and Insulin during Fasting and Subsequent Refeeding Periods in Shiba Goats
- Prominent Expression of Spinocerebellar Ataxia Type-1 (SCA1) Gene Encoding Ataxin-1 in LH-Producing Cells, LβT2
- Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
- Expression of Porcine FSHβ Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Transgenic Rats
- Synthesis of Peptide Thioesters using N-Substituted Aniline Derivatives
- Translocation of Basic Peptides through Human Cell Membranes
- Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats
- Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
- 周排卵期の神経内分泌
- 1995年度島村賞受賞講演論文 : 黄体形成ホルモンのパルス状分泌を制御する中枢機構
- Influence of an Amino Acid Sequence on Kinetics of Peptide Bond Cleavage Reaction Induced by a Stimulus-responsive Amino Acid
- Application of Peptide Thioacids to NCL-type Sequential Condensation of Peptide Fragments
- Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere
- Analysis of Pulsatile and Surge-like Luteinizing Hormone Secretion with Frequent Blood Sampling in Female Mice
- Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker
- 男女共同参画の明るい未来に向けて
- Synthesis and Evaluation of CXCR4-derived Peptides Targeting the Development of AIDS Vaccines
- 雌ラットにおけるアロキサン第4脳室内投与がパルス状黄体形成ホルモン分泌に及ぼす影響
- Functional Characterization of Kisspeptin Receptor Ligands : Activation of Neuropeptide FF Receptors
- Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells
- Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats
- Development of Stimulus Responsive Thiol Releasing System for Controlling Activity of Cysteine Protease
- Synthesis of Nonhydrolyzable AMPylated Amino Acid Analogues for Uncovering the Physiological Role of AMPylation
- Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins
- Native Chemical Ligation Using N-peptidyl Anilide as Crypto-thioester
- Enantioselective Synthesis of Stimulus-responsive Amino Acid via Pyrrolidinyl Tetrazole Catalyzed Asymmetric α-Amination of Aldehyde
- Synthesis and Biological Evaluation of CXCL14 and Its Derivatives
- Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats
- 生殖機能の環境による調節 : その神経内分泌学的機序
- Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
- 視床下部弓状核はグルタミン酸によるGnRH放出を促進するエストロジェンの効果を仲介する
- キスペプチン/メタスチン-繁殖を制御する新規神経ペプチド
- Analysis of Pulsatile and Surge-like Luteinizing Hormone Secretion with Frequent Blood Sampling in Female Mice
- Intense Blue Fluorescence of Tag-Probe Systems Based on a Leucine Zipper Assembly
- Designed Antigens Based on the Dynamic Structural Changes of gp41 for Development of Effective HIV -1 Vaccines
- Development of Designed Bivalent Ligands for CXCR4 and Their Function on Receptor Binding
- 腟内留置型プロジェステロン製剤(PRID)を用いたブタの発情同期化
- Caged Ceramide Which Releases Parent Ceramide After UV-Induced Amide Bond Cleavage Followed by Intramolecular O-N Acyl Transfer
- Double-Kinetically Controlled Proline Ligation
- N-Sulfanylethylanilide Peptide : A Peptide Thioester Equivalent Which Can Directly Participate in Native Chemical Ligation
- 男女共同参画推進による科学技術分野の活性化のために