Otaka Akira | Graduate School Of Pharmaceutical Sciences Kyoto University

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概要

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著作論文

Synthesis of a CC Chemokine, vMIP-II, Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Its Biological Activity
Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
Development of Specific CXCR4 Inhibitors Based on an Anti-HIV Peptide, T140, and Their Structure-Activity Relationships Study
HIV-cell Fusion Inhibitors Targeted to the HIV Second Receptor : T22 and Its Downsized Analogs with High Activity
Synthesis of CXCR4 Antagonists, T140 Derivatives with Improved Biostability, and Their SAR Study
Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion
Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isostere and Its Biological Activity
Design and Synthesis of Highly Active Anti-HIV Peptide Based on Gp41-C34 Peptide
Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
Synthesis of (Z)-Alkene cis-Ala-Pro Mimetics Using Organocopper Reagents
Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
A New Practical Strategy for the Synthesis of Long-Chain Phosphopeptide
Synthesis of Nonhydrolyzable Phosphothreonine Derivatives and Their Practical Application to Peptide Synthesis
Identification of Biologically Active Peptides in Laminin-1
Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
HSP47-Binding Structural Epitopes in Triple Helical Collagen
Synthesis of (Z)-Alkene cis-Xaa-Pro Type Dipeptide Isosteres Using Organocopper-Mediated Anti-S_N2' Reactions
4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α, β-enoates and Their Application
Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biologically Active Peptide. Part 1
Stereoselective Synthesis of CF_2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptides
Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
Interactions between Local Anesthetics and Na^+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by ^1H-NMR Spectroscopy
Translocation of Basic Peptides through Human Cell Membranes
Synthesis of Peptide Thioester Based on N-S Acyl Transfer Utilizing Cysteine-derived Acyloxazolidinone with Practical Application to Peptide Synthesis
New Strategy for The Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement"
Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
Synthesis of (E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents
Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Dipeptide Isosteres Utilizing Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions
Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere
P-202 DEVELOPMENT OF PHOTO-TRIGGERED SELF-PROCESSING PEPTIDES
Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organocopper or SmI_2 Reagents

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