Otaka Akira | Institute Of Health Biosciences Graduate School Of Pharmaceutical Sciences The University Of Tokushi

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概要

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著作論文

Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
Development of Stimulus-Responsive Amino Acid with Peptide Bond-Cleavage Ability and Its Application to a Nucleocytoplasmic Shuttle Peptide
Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
Synthesis of (Z)-Alkene cis-Ala-Pro Mimetics Using Organocopper Reagents
Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
Synthesis of (Z)-Alkene cis-Xaa-Pro Type Dipeptide Isosteres Using Organocopper-Mediated Anti-S_N2' Reactions
4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
Synthesis of Peptide Thioesters using N-Substituted Aniline Derivatives
Translocation of Basic Peptides through Human Cell Membranes
Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
Influence of an Amino Acid Sequence on Kinetics of Peptide Bond Cleavage Reaction Induced by a Stimulus-responsive Amino Acid
Application of Peptide Thioacids to NCL-type Sequential Condensation of Peptide Fragments
Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere
Development of Stimulus Responsive Thiol Releasing System for Controlling Activity of Cysteine Protease
Synthesis of Nonhydrolyzable AMPylated Amino Acid Analogues for Uncovering the Physiological Role of AMPylation
Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins
Native Chemical Ligation Using N-peptidyl Anilide as Crypto-thioester
Enantioselective Synthesis of Stimulus-responsive Amino Acid via Pyrrolidinyl Tetrazole Catalyzed Asymmetric α-Amination of Aldehyde
Synthesis and Biological Evaluation of CXCL14 and Its Derivatives
Caged Ceramide Which Releases Parent Ceramide After UV-Induced Amide Bond Cleavage Followed by Intramolecular O-N Acyl Transfer
Double-Kinetically Controlled Proline Ligation
N-Sulfanylethylanilide Peptide : A Peptide Thioester Equivalent Which Can Directly Participate in Native Chemical Ligation

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