Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus(Virology)
スポンサーリンク
概要
- 論文の詳細を見る
CXC-chemokine receptor 4 (CXCR4) functions as a receptor for feline immunodeficiency virus (FIV). Although we previously found that a CXCR4 antagonist, T140, inhibited the FIV replication in vitro, it was not effective in cats infected with FIV because of its low stability in feline serum. To resolve this problem, several T140 derivatives have been developed. Here, we examined the efficacy of T140 analogs, TF14016 and TF14013, on the inhibition of FIV infection. These compounds were shown to significantly inhibit the syncytia formation in CXCR4-expressing cells after co-cultivation with FIV-infected cells and the replication of FIV in a feline lymphoid cultured cell line. These results indicated that TF14016 and TF14013 could be useful as antiviral drugs for cats infected with FIV.
- 社団法人日本獣医学会の論文
- 2009-01-25
著者
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TSUJIMOTO Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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FUJINO Yasuhito
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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OHNO Koichi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Tsujimoto Hajime
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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束村 博子
名古屋大学 大学院生命農学研究科生殖科学研究分野
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束村 博子
名古屋大院生命農学
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束村 博子
名古屋大学大学院生命農学研究科生命技術科学専攻
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Goto-Koshino Yuko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Mizukoshi Fuminori
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Baba Kenji
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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SETOGUCHI-MUKAI Asuka
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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FUJII Nobutaka
Graduate School of Pharmaceutical Sciences, Kyoto University
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OISHI Shinya
Graduate School of Pharmaceutical Sciences, Kyoto University
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Ohno Koichi
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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TAMAMURA Hirokazu
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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Oishi S
Graduate School Of Pharmaceutical Sciences Kyoto University
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Oishi Shinya
Graduate School Of Pharmaceutical Sciences Kyoto University
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Oishi Shinya
Laboratory Of Medicinal Chemistry Ccr Nci Nih
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Fujino Yasuhito
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Baba Kenji
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Fujii N
Graduate School Of Pharmaceutical Sciences Kyoto University
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Fujii Nobutaka
Graduate School Of Pharmaceutical Sciences Kyoto University
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Fujii Nobutaka
Department Of Pharmaceutical Manufacturing Graduate School Of Pharmaceutical Science Kyoto Universit
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Tamamura H
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Tamamura Hirokazu
Faculty Of Pharmaceutical Sciences Kyoto University
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Tamamura Hirokazu
Dept. Of Molecular Recognition Inst. Of Biomaterials And Bioengineering Tokyo Medical And Dental Uni
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Ohno Koichi
Department Of Veterinary Internal Medicine The University Of Tokyo
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Ohno Koichi
Department Of Chemical Engineering Faculty Of Engineering Niigata University
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Fujino Yasuhito
Univ. Tokyo Tokyo Jpn
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Tsujimoto Hajime
Univ. Tokyo Tokyo Jpn
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Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
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Tamamura Hirokazu
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Mizukoshi Fuminori
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Baba Kenji
Laboratory Of Viral Pathogenesis Center For Emerging Virus Research Institute For Virus Research Kyo
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Goto-Koshino Yuko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SETOGUCHI-MUKAI Asuka
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SETOGUCHI-MUKAI Asuka
Department of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
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