In Vitro Anti-Human Immunodeficiency Virus Activity of Polysaccharide from Rhizophora mucronata Poir.

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概要

• 論文の詳細を見る

• A polysaccharide was extracted with 1% sodium carbonate from the bark of Rhizophora mucronata and its antiviral activities against human immunodeficiency virus (HIV) were assessed by an in vitro cell culture system. The anti-HIV activity of the alkaline extract was mainly recovered in the 25-75% ethanol-precipitated fraction. Rhizophora mucronata polysaccharide (RMP) protected MT-4 cells from the HIV-induced cytopathogenicity and blocked the expression of HIV antigens. RMP completely inhibited the viral binding to the cell and the formation of syncytium upon cocultivation of MOLT-4/HIV-1_<IIIB>cells and MOLT-4 cells. These results suggest that RMP inhibited early steps of the virus life cycle especially virus adsorption to the cell.

• 社団法人日本農芸化学会の論文
• 1999-07-23

著者

• Nakashima Hideki

  Department of Microbiology and Immunologu,Kagoshima University Dental School

• Nakashima H

  Graduate School Of Pharmaceutical Sciences Kyoto University

• YAMAMOTO Naoki

  Department of Microbiology, Tokyo Medical and Dental University School of Medicine

• Yamamoto Naoki

  Department Of Bioregulation Research Nagoya City University Medical School

• Yamamoto N

  Ehime Univ. Ehime Jpn

• Premanathan Mariappan

  Department of Microbiology and Immunology, Kagoshima University DentalSchool

• Premanathan Mariappan

  Department Of Microbiology And Immunology Kagoshima University Dental School

• Nakashima Hideki

  Department Of Microbiology And Immunology Kagoshima University Dental School

• Nakano Hiroaki

  Departmetnt Of Pharmacy Hyogo University Of Health Sciences

• Nakashima Hideki

  Department Of Microbiology St. Marianna University School Of Medicine

• Nakashima Hideki

  Department Of Advanced Energy Engineering Science Interdisciplinary Graduate School Of Engineering S

• Nakashima Hideki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• KATHIRESAN Kandasamy

  Centre of Advanced Study in Marine Biology, Annamalai University

• Nakashima H

  Departmetnt Of Pharmacy Hyogo University Of Health Sciences

• Nishikawa Hiroki

  Departmetnt Of Pharmacy Hyogo University Of Health Sciences

• Yamamoto Naoki

  Department Of Bioinformatics Faculty Of Engineering Soka University

• Nishikawa Hiroki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kathiresan Kandasamy

  Centre Of Advanced Study In Marine Biology Annamalai University

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