Bioorganic Synthesis of End-capped HIV-1 Fusion Inhibitor SC35EK

スポンサーリンク

概要

• 論文の詳細を見る
• 2009-03-01

著者

• OHNO Hiroaki

  Graduate School of Pharmaceutical Sciences, Osaka University

• FUJII Nobutaka

  Graduate School of Pharmaceutical Sciences, Kyoto University

• OISHI Shinya

  Graduate School of Pharmaceutical Sciences, Kyoto University

• MATSUOKA Masao

  Institute for Virus Research, Kyoto University

• Oishi S

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Oishi Shinya

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Oishi Shinya

  Laboratory Of Medicinal Chemistry Ccr Nci Nih

• Okamura H

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Ohno Hiroaki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Matsuoka Masao

  Institute For Virus Research Kyoto University

• WATANABE Kentaro

  Graduate School of Pharmaceutical Sciences, Kyoto University

• IZUMI Kazuki

  Institute for Virus Research, Kyoto University

• KODAMA Eiichi

  Institute for Virus Research, Kyoto University

• Fujii N

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Fujii Nobutaka

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Fujii Nobutaka

  Department Of Pharmaceutical Manufacturing Graduate School Of Pharmaceutical Science Kyoto Universit

• Izumi Kazuki

  Institute For Virus Research Kyoto University

• Kodama Eiichi

  Institute For Virus Research Kyoto University

• Mizumoto Makiko

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Watanabe Kunihiko

  Division Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Kyoto Prefectur

• KAJIWARA Kazumi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• TOKIWA Rei

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Kajiwara Kazumi

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Tokiwa Rei

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Watanabe Kentaro

  Graduate School Of Pharmaceutical Sciences Kyoto University

関連論文

• Central Administration of Neuropeptide B, But not Prolactin-Releasing Peptide, Stimulates Cortisol Secretion in Sheep
• Androgen Induces Production of Male Effect Pheromone in Female Goats
• Stereodivergent Synthesis of Chiral 2-Alkenylaziridines : Palladium(0)-Catalyzed 2,3-cis-Selective Aziridination and Base-Mediated 2,3-trans-Selective Aziridination
• Synthesis of a CC Chemokine, vMIP-II, Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Its Biological Activity
• Development of Chemical Probes for the Chemokine Receptor CXCR4 Involving Radiolabeled T140 Analogs
• Development of the Chemokine Receptor CXCR4 Antagonists as Multi-Pharmaceutical Agents Involving a New Class of Low Molecular Weight Antagonists
• P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists
• Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
• The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
• New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
• A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
• CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
• Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
• Development of Specific CXCR4 Inhibitors Based on an Anti-HIV Peptide, T140, and Their Structure-Activity Relationships Study
• Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1
• HIV-cell Fusion Inhibitors Targeted to the HIV Second Receptor : T22 and Its Downsized Analogs with High Activity
• Design, Synthesis and Activity of Shortened Analogs of an Anti-HIV Peptide, T22
• Helix Inducible Motifs Affect Helicity and Bioactivity of Anti-HIV Peptides
• Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity
• STRUCTURE-ACTIVITY RELATIONSHIPS OF TACHYPLESIN ANALOGS AS ANTI-HIV AGENT
• Synthesis of CXCR4 Antagonists, T140 Derivatives with Improved Biostability, and Their SAR Study
• Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion
• Synthesis and Biological Activity of Bombesin Analogues Containing (E)-Alkene Dipeptide Isosteres
• Application of β-Branched Allylglycine Equivalents to Macrocyclic Grb2 SH2 Domain-Binding Inhibitors
• Total Synthesis of (±)-Stemodinone via an EfficientRing-Exchange Strategy
• Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isostere and Its Biological Activity
• Identification of a Polyphemusin Analog(T22)-Zn(II) Complex by Mass Spectrometric Analysis and Its Anti-HIV Activity
• Identification of Binding Proteins of an Anti-HIV Peptide, T22
• Synthesis and Application of Novel Fluorescence-Labeled CXCR4 Antagonists
• Design and Synthesis of Highly Active Anti-HIV Peptide Based on Gp41-C34 Peptide
• P-467 Structure-activity relationship study on GPR54 agonists
• Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
• Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide
• Synthesis of (Z)-Alkene cis-Ala-Pro Mimetics Using Organocopper Reagents
• Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres
• Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
• Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
• Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
• Properties of Intracellular Fragment Peptides of Mouse Prostaglandin E_2 Receptor EP3 Isoform
• Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus(Virology)
• Synthetic Studies of Tokaramide A and Miraziridine A Isolated from Marine Sponge Theonella aff. mirabilis
• P-39 2'-DEXY-4'-C-ETHYNYL-2-FLUOROADENOSINE, A NRTI THAT COULD BE AN IDEAL DRUG FOR BOTH HIV-AND HBV-INFECTIONS
• A New Practical Strategy for the Synthesis of Long-Chain Phosphopeptide
• Synthesis of Nonhydrolyzable Phosphothreonine Derivatives and Their Practical Application to Peptide Synthesis
• Practical Phosphoeptides Synthesis Using Dimenthylphosphono Amino Acids (No.2)
• Evaluation of Scopadulciol-Related Molecules for Their Stimulatory Effect on the Cytotoxicity of Acyclovir and Ganciclovir against Herpes Simplex Virus Type 1 Thymidine Kinase Gene-Transfected HeLa Cells
• Specific Fluorescence Labeling of Membrane Receptors in Living Cells using Coiled-coil Tag
• Fluoroalkene Skeleton as a Peptide Bond Mimetic : Its Scope and Limitations
• Establishment and Clinical Application of an Enzyme Immunoassay for Metastin to Determination of the Human Plasma Levels
• A Novel Oxazolidine Linker for the Synthesis of Peptide Aldehydes
• Structure-Activity Relationship Studies on GPR54 Agonists
• Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
• Cyclic Analogs Derived from Laminin Enhanced the Biological Activities
• Biological Activity of a Cyclic Peptide from Laminin α1 Chain Loop Region
• Synthesis and Application of Novel Phosphotyrosyl Mimetics to Grb2 SH2 Domain-Binding Inhibitors
• Construction of Tricyclic Enone, a Common Precursor for Aphidicolane and Stemodane B/C/D-Ring System
• Synthesis of (Z)-Alkene cis-Xaa-Pro Type Dipeptide Isosteres Using Organocopper-Mediated Anti-S_N2' Reactions
• 4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
• Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α, β-enoates and Their Application
• Structure-Activity Relationship Study of CXCR4 Antagonists on the Cyclic Pentapeptide Scaffold : Identification of New Pharmacophore Moieties
• Leukemogenesis of Adult T-Cell Leukemia
• Oligoarginine-mediated Delivery of Bioactive Peptides into Living cells
• Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biologically Active Peptide. Part 1
• Identification of Novel HIV-1 Fusion Inhibitors by Template-Assisted Peptide Aldehyde Ligation
• Structure Activity Relationship Study of the Helix-inducible Motifs in HIV Fusion Inhibitors
• X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant
• Bioorganic Synthesis of End-capped HIV-1 Fusion Inhibitor SC35EK
• Simultaneous Observation of the GnRH Pulse Generator Activity and Plasma Concentrations of Metabolites and Insulin during Fasting and Subsequent Refeeding Periods in Shiba Goats
• Effect of a New Bombesin Receptor Antagonist, (E)-Alkene Bombesin Isostere, on Amylase Release from Rat Pancreatic Acini
• Stereoselective Synthesis of CF_2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptides
• Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
• Body Growth and Plasma Concentrations of Metabolites and Metabolic Hormones during the Pubertal Period in Female Shiba Goats
• Interactions between Local Anesthetics and Na^+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by ^1H-NMR Spectroscopy
• SOMATIC ALTERATIONS IN ADULT T-CELL LEUKEMIA CELLS
• Translocation of Basic Peptides through Human Cell Membranes
• Development of Novel GPR54 Agonists with Resistance to Degradation by MMP
• Diastereoselective Synthesis of (Z)-Fluoroalkene Dipeptide Isostere and the Application to a HIV Membrane Fusion Inhibitor
• Diastereoselective Synthesis of Trifluoromethylalkene Dipeptide Isosteres Based on Nucleophilic Trifluoromethylation
• Synthesis of Peptide Thioester Based on N-S Acyl Transfer Utilizing Cysteine-derived Acyloxazolidinone with Practical Application to Peptide Synthesis
• A Highly Stereoselective Synthesis of the Functionalized (E)-Alkene Dipeptide Isostere of Trp-Val via Organocyanocopper-Lewis Acid Mediated Reaction
• A Highly Stereoselective Synthesis of The Functionalized (E)-Alkene Dipeptide Isostere of Trp-Val via Organocyanocopper-Lewis Acid Mediated Reaction
• New Strategy for The Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement"
• Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
• Utility of Plasma Bioactive Peptides Levels as Biomarkers
• Synthesis of (E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents
• Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Dipeptide Isosteres Utilizing Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions
• Nitric Oxide in the Ventromedial Nucleus of the Hypothalamus Mediates Action of Estrogen on Goat Ingestive Behavior
• Alteration of Ingestive Behavior and Plasma Metabolites by Estrogen in Ovariectomized Goats
• Development of Useful Reactions Involving Tandem Cyclizations Based on the Novel Reactivities of Allenic Compounds
• Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere
• Effects of Brief Exposure of Male Pheromone on Multiple-Unit Activity at Close Proximity to Kisspeptin Neurons in the Goat Arcuate Nucleus
• Stereoselective Synthesis of Tyr-Orn Type Alkene Dipeptide Isosteres and Their Application to Bioactive Peptides
• Functional Characterization of Kisspeptin Receptor Ligands : Activation of Neuropeptide FF Receptors
• Synthetic Studies on Coibamide A
• Guest editorial : a new era of ATL and HTLV-1 research
• High-Throughput Turbidimetric Screening for Heparin-Neutralizing Agents and Low-Molecular-Weight Heparin Mimetics
• Chronic Peripheral Administration of Kappa-Opioid Receptor Antagonist Advances Puberty Onset Associated with Acceleration of Pulsatile Luteinizing Hormone Secretion in Female Rats
• Enhanced Plasmid DNA Transfer into Tumor Cells by Nanoparticle Composed of Cholesteryl Triamine and Diamine
• Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows
• Synthesis and Investigation of Novel Metal Complexes of Deferriferrichrysin

もっと見る 閉じる

スポンサーリンク