A Highly Stereoselective Synthesis of the Functionalized (E)-Alkene Dipeptide Isostere of Trp-Val via Organocyanocopper-Lewis Acid Mediated Reaction

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概要

• 論文の詳細を見る

• A stereocontrolled synthesis of the (E)-alkene dipeptide isostere of Trp-Val is described. The stereospecific α-alkylation of the δ-amino-γ-mesyloxy-α, β-unsaturated ester via the organocyanocopper-Lewis acid mediated reaction, based on 1,3-transfer of chirality, was successfully applied for the key step in the synthetic sequence.

• 公益社団法人日本薬学会の論文
• 1997-08-15

著者

• FUJII Nobutaka

  Faculty of Pharmaceutical Sciences, Kyoto University

• Ibuka T

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Ibuka Toshiro

  Faculty Of Pharmaceutical Sciences Kyoto University

• Ibuka Toshiro

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Fujii N

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Fujii Nobutaka

  Faculty Of Pharmaceutical Science Kyoto University

• Noda M

  Shimadzu Corp. Kyoto Jpn

• HABASHITA Hiromu

  Faculty of Pharmaceutical Sciences, Kyoto University

• NODA Masaki

  Technology Research Laboratory, Shimadzu Co.,

• Habashita H

  Faculty Of Pharmaceutical Sciences Kyoto University

• Habashita Hiromu

  Faculty Of Pharmaceutical Sciences Kyoto University

• Noda Masaki

  Technology Research Laboratory Shimadzu Corp.

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