Studies on Peptides. CLIII. : Application of the Hard-Acid Deprotecting Procedure to the Synthesis of Ovine Corticotropin Releasing Factor (oCRF)(Organic,Chemical)

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概要

• 論文の詳細を見る

• A 41-residue peptide corresponding to the entire amino acid sequence of ovine corticotropin releasing factor (oCRF) was synthesized by assembling ten peptide fragments of established purity, followed by hard-acid deprotection with 1 M trimethylsilyl trifluoromethanesulfonate in trifluoroacetic acid. β-Cycloheptylaspartate was employed to minimize base-catalyzed succinimide formation. When tested by in vivo assay, synthetic oCRF was as active as synthetic hCRF in terms of ability to release immunoreactive corticotropin.

• 公益社団法人日本薬学会の論文
• 1987-09-25

著者

• FUJII Nobutaka

  Faculty of Pharmaceutical Sciences, Kyoto University

• Imura Hiroo

  The 2nd Division, Dept. of Medicine, Kyoto Univ. School of Medicine

• NAKAMUTA HIROMICHI

  Department of Parmacology, Setsunan University

• KOIDA MASAO

  Department of Parmacology, Setsunan University

• Akaji K

  Kyoto Univ. Kyoto Jpn

• Akaji Kenichi

  Faculty Of Pharmaceutical Sciences Kyoto University

• FUNAKOSHI Susumu

  Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto

• Fujii Nobutaka

  Faculty Of Pharmaceutical Science Kyoto University

• KOGIRE MASAFUMI

  Faculty of Medicine Kyoto University

• YAJIMA HARUAKI

  Faculty of Pharmaceutical Sciences, Kyoto University

• Yajima H

  Kyoto Univ. Kyoto Jpn

• Yajima Haruaki

  Faculty Of Pharmaceutical Sciences Kyoto University

• Tsukada Toshihiko

  The 2nd Internal Medicine Kyoto University

• Watanabe Kazuhide

  Faculty Of Pharmaceutical Sciences Kyoto University

• Koida Masao

  Department Of Parmacology Setsunan University

• Fukata J

  Kochi Medical School Kochi

• Fukata Junichi

  Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine

• Nomizu Motoyoshi

  Faculty Of Pharmaceutical Sciences Kyoto University

• FUKATA JUNICHI

  The 2nd Internal Medicine, Kyoto University

• Funakoshi S

  Kyoto Univ. Kyoto Jpn

• Funakoshi Susumu

  Faculty Of Pharmaceutical Sciences Kyoto University Kyoto:department Of Microbiology Tokyo Medicinal

• Nakamuta H

  Department Of Pharmacology Hiroshima International University

• Nakamuta Hiromichi

  Department Of Parmacology Setsunan University

• Imura Hiroo

  The 2nd Internal Medicine Kyoto University

• Imura Hiroo

  The 2nd Dept. Of Internal Medicine Kyoto Univ.

• YAJIMA HARUAKI

  Faculty of Pharmaceutical Science, Kyoto University

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