Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Ostrich Adrenocorticotropic Hormone
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概要
- 論文の詳細を見る
The nonatriaoontapeptide corresponding to the entire amino acid sequence of ostrich adrenocorticotropic hormone (ACTH) was synthesized by successive condensations of four peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-OH, Boc-(5-10)-OH and Z-(1-4)-NHNH_2,with H-(20-39)-OBzl, a synthetic intermediate of ostrich-type corticotropin-like intermediate lobe peptide, followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in TFA. The synthetic peptide exhibited an in vivo steroidogenic potency of 0.8 relative to synthetic human ACTH.
- 公益社団法人日本薬学会の論文
- 1982-03-25
著者
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中村 益久
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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安村 貢一
Fujii, Memorial Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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岡本 憲治
Kyoto Pharmaceutical University
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田中 明
Shionogi Research Laboratory Shionogi And Co. Ltd.
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矢島 治明
京都大学
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YAJIMA HARUAKI
Faculty of Pharmaceutical Sciences, Kyoto University
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Yajima Haruaki
Faculty Of Pharmaceutical Sciences Kyoto University
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安村 貢一
Kyoto College of Pharmacy
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島村 真一
Kyoto College of Pharmacy
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中村 益久
Shionogi Research Laboratories Shionogi & Co. Ltd.
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ODAGUCHI KUNIHIRO
Shionogi Research Laboratory, Shionogi Co. Ltd.
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TANAKA AKIRA
Shionogi Research Laboratory, Shionogi Co. Ltd.
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Odaguchi Kunihiro
Shionogi Research Laboratory Shionogi Co. Ltd.
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安村 貢一
Fujii Memorial Research Institute Otsuka Pharmaceutical Co. Ltd.
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TANAKA AKIRA
Shionogi Research Laboratory
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YAJIMA HARUAKI
Faculty of Pharmaceutical Science, Kyoto University
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ODAGUCHI KUNIHIRO
Shionogi Research Laboratory
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