Studies on Peptides. CXLVII. Synthesis of Valosin, a Novel 25-Residue Peptide from Porcine Intestine(Organic,Chemical)
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概要
- 論文の詳細を見る
A 25-residue peptide isolated from porcine intestine, designated valosin, was synthesized by assembling seven peptide fragments of established purity, followed by deprotection with 1 M trifluoromethanesulfonic acid in trifluoroacetic acid. γ-Cycloheptylglutamate, [Glu(OChp)], was employed to suppress pyrrolidone formation during fragment condensation. Before deprotection, Met(O) was reduced with phenylthiotrimethylsilane and trimethylsilyl trifluoromethanesulfonate. The effect of the synthetic peptide on arterial pressure, blood flow in the superior mesenteric artery, pancreatic capillary blood flow and pancreatic exocrine secretion was examined in dogs, but no significant dose-dependent response was observed. In rats, synthetic valosin stimulated pancreatic secretion, but showed no anti-gastric activity.
- 1987-02-25
著者
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小切 匡史
岸和田市民病院外科
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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高折 恭一
京都大学肝胆膵・移植外科
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土井 隆一郎
大津赤十字病院外科
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土井 隆一郎
京都大学第1外科
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赤路 健一
Faculty of Pharmaceutical Sciences
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青野 充
First Department of Internal Medicine, Faculty of Medicine
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森賀 本幸
First Department of Internal Medicine, Faculty of Medicine
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井上 一知
First Department of Internal Medicine, Faculty of Medicine
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戸部 隆吉
First Department of Surgery, Faculty of Medicine
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矢島 治明
京都大学
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矢島 治明
京大・薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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田中 理紀
Faculty of Pharmaceutical Sciences, Kyoto University
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角 昭一郎
First Department of Surgery, Faculty of Medicine, Kyoto University
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小切 匡史
First Department of Surgery, Faculty of Medicine, Kyoto University
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高折 恭一
First Department of Surgery, Faculty of Medicine, Kyoto University
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土井 隆一郎
First Department of Surgery, Faculty of Medicine, Kyoto University
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田中 理紀
Faculty Of Pharmaceutical Sciences Kyoto University
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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