Studies on Peptides. XCVII. Synthesis of Porcine Glu^8-Vasoactive Intestinal Polypeptide (VIP)
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概要
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The synthesis of Glu^8-vasoactive intestinal polypeptide (porcine VIP) is described. A 1 M solution of trifluoromethanesulfonic acid-thioanisole (1 : 1 equiv.) in TFA was found to cleave all the protecting groups employed, Z, Z (OMe), Bzl and Mts, suppressing the acid-catalyzed aminosuccinimide formation of the Asp residue (position 3) with the free carboxyl group. The activity of Glu^8-VIP was 1/7-1/8 of that of synthetic porcine VIP.
- 社団法人日本薬学会の論文
- 1980-07-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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武山 正治
Department of Clinical Pharmacy, Oita Medical University
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村上 元庸
School Of Medicine Kyoto University
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武山 正治
Department Of Clinical Pharmacy Oita Medical University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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