Synthesis of Porcine Motilin and Its D-Phe^1-Analog by the Use of Methanesulfonic Acid
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概要
- 論文の詳細を見る
Motilin and [D-Phe^1]-motilin were synthesized via the corresponding sulfoxide (Met^<13>). The protected Met (O)^<13>-motilin and [D-Phe^1,Met (O)^<13>]-motilin, in which Met residue was substituted by Met (O) residue, were constructed from three suitable subunits, respectively. The protected peptides were deblocked by methanesulfonic acid in the presence of anisole to obtain Met (O)^<13>-motilin and its D-Phe^1-derivative, and the resulting Met (O)-peptides were finally reduced by thiol to give the desired docosapeptides, motilin and D-Phe^1-motilin.
- 社団法人日本薬学会の論文
- 1978-01-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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藤野 政彦
武田薬品工業
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藤野 政彦
武田薬品中央研
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北田 千恵子
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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北田 千恵子
Discovery Research Division Takeda Chemical Industries Ltd.
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Kitada Chieko
Discovery Research Division Takeda Chemical Industries Ltd
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脇舛 光広
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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脇舛 光広
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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