Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Dogfish Adrenocorticotropic Hormone (Squalus acantias)

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概要

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• The nonatriacontapeptide corresponding to the entrie amino acid sequence of dogfish adrenocorticotropic hormone was synthesized by successive condensations of three peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-NHNH_2 and Z-(1-10)-OH, with H-(20-39)-OBzl, a synthetic intermediate of dogfish corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the in vivo steroidogenetic activity of 21.3 IU/mg.

• 公益社団法人日本薬学会の論文
• 1979-02-25

著者

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 安村 貢一

  Fujii, Memorial Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 田中 明

  Shionogi Research Laboratory, Shionogi Co., Ltd.

• 岡本 憲治

  Kyoto Pharmaceutical University

• 田中 明

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 島村 真一

  Kyoto College of Pharmacy

• 安村 貢一

  Fujii Memorial Research Institute Otsuka Pharmaceutical Co. Ltd.

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