Studies on Peptides. LXIV. Synthesis of the Tritetracontapeptide corresponding to the Entire Amino Acid Sequence of Porcine Gastric Inhibitory Polypeptide (GIP)
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概要
- 論文の詳細を見る
The tritetracontapeptide corresponding to the entire amino acid sequence of porcine gastric inhibitory polypeptide (GIP) was synthesized starting with the C-terminal octadecapeptide, the synthesis of which was previously reported. The hydrogen fluoride procedure was employed to remove all protecting groups employed at the final stage of the synthesis. Trichloroethyloxycarbonylhydrazine was used to prepare alternatively the nonacosapeptide, a cyanogen bromide fragment of GIP, H-(GIP 15-43)-OH. Synthetic GIP suppressed gastric acid secretion stimulated by histamine as well as tetragastrin in Heidenhein pouch dogs. H-(GIP 15-43)-OH exhibited approximately one quarter of the activity of the whole molecule. Association of the insulin release activity in GIP was synthetically confirmed.
- 社団法人日本薬学会の論文
- 1976-10-25
著者
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藤村 昌樹
滋賀医大・ii外
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鳥塚 莞爾
京都大学医学部放射線核医学
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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小川 博
Faculty Of Pharmaceutical Sciences Kyoto University
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安達 秀樹
School of Medicine, Kyoto University
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田港 朝彦
School of Medicine, Kobe University
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辺見 公雄
京都大学第1外科
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辺見 公雄
京大第2外科
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安達 秀樹
University Hospital Faculty Of Medicine Kyoto University
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窪田 実
Central Research Institute, Daiichi Seiyaku Co., Ltd.
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窪田 実
Central Research Institute Daiichi Seiyaku Co. Ltd.
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田港 朝彦
School Of Medicine Kobe University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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