Studies on Peptides. LXIX. Selective Removal of Acid Labile α-Amino Protecting Groups with Dilute Sulfonic Acids
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概要
- 論文の詳細を見る
Among various dilute sulfonic acids tested, 2 to 4N ethanesulfonic acid in acetic acid or methylenechloride was found suitable as a deprotecting reagent for the acid labile α-amino protecting groups, such as Boc and Z(OMe), which are currently removed by trifluoroacetic acid or dilute hydrochloric acid, since the deprotection occured selectively within 60 minutes at room temperature leaving intact other side chain protecting groups, such as Z, benzyl ester, S-p-methoxybenzyl and N^G-p-methoxybenzenesulfonyl groups. This reagent was applied to the synthesis of three model peptides ; Met and Leu-enkephalin and endorphin.
- 社団法人日本薬学会の論文
- 1977-04-25
著者
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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小川 博
Faculty Of Pharmaceutical Sciences Kyoto University
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船越 奨
Faculty of Pharmaceutical Sciences
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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