Studies on Peptides. CXII. Alternative Synthesis of Heptacosapeptide, a New Gastrointestinal Polypeptide
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概要
- 論文の詳細を見る
A recently found gastrointestinal hormone, PHI (heptacosapeptide), was synthesized in a different manner from that of Moroder et al. [Z. Naturforsch., 37b, 772 (1982) ]. Our synthesis was carried out by successive azide condensation of six peptide fragments (23-27,19-22,15-18,11-14,7-10,and 1-6), followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The deprotected peptide was purified by gel-filtration on Sephadex G-25,followed by ion-exchange chromatography on CM-Biogel A and reverse phase high-performance liquid chromatography on μBondapak C_<18>. The homogeneous product thus obtained produced a remarkable decrease in systemic blood pressure in anesthetized rats. In addition, N^α-biotinyl-PHI was synthesized for histochemical receptor-binding studies.
- 公益社団法人日本薬学会の論文
- 1983-10-25
著者
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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水田 和彦
First Department Of Internal Medicine Faculty Of Medicine:kyoto University
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李 惟
Department Of Molecular Biology Jilin University
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矢島 治明
京都大学
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森賀 本幸
School of Medicine Kyoto University
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水田 和彦
School of Medicine Kyoto University
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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季 惟
Chemistry Department, Jilin University
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季 惟
京都大学 薬
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