Studies on Peptides. CXXXVII. : Conventional Solution Synthesis of Porcine Hypothalamic Growth Hormone Releasing Factor (pGRF)
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概要
- 論文の詳細を見る
A tetratetracontapeptide amide corresponding to the entire amino acid sequence of porcine hypothalamic growth hormone releasing factor (pGRF) was synthesized by a conventional solution method, by assembling nine peptide fragments followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The synthetic peptide was as active as synthetic human GRF-44-NH_2 in an in vitro assay. A new substituted hydrazine, 2,2,2-trichloro-tert-butoxycarbonyl hydrazine, was employd for the preparation of a hydrazide containing Glu(OBzl). In the deprotecting step, Me_2Se was empliyed to facilitate acidolytic cleavage of protecting groups, as well as reduction of Met(O).
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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藤井 信孝
京都大学薬学部
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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関 等
住友製薬研究所
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長田 明彦
住友製薬研究所
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木曽 良明
Kyoto College of Pharmacy
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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霜倉 正徳
Kyoto Pharmaceutical University
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長田 明彦
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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津田 正文
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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関 等
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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甲斐 啓幸
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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甲斐 啓幸
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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霜倉 正徳
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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藤井 信孝
京都大学
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霜倉 正徳
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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津田 正文
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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長田 明彦
Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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