有機スルホン酸脱保護法によるペプチドの合成研究
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概要
- 論文の詳細を見る
In peptide synthesis, any desired peptide can not be obtained in a satisfactory yield and with a high degree of purity, without having a suitable deprotecting tool at the final stage of the synthesis. Moreover, the choice of a final deprotecting reagent determines the main synthetic strategy. In order to explore the suitable deprotecting conditions, the methanesulfonic acid and trifluoromethanesulfonic aoid deprotecting procedures have been examined. After investigating a few of side reactions which can take place under the above deprotecting conditions, the validity of these deprotecting reagents was demonstrated by the syntheses of several biologically active polypeptides including bovine pancreatic ribonuclease (RNase) A. The scope and limitation of these organosulfonic acid deprotecting reagents in peptide synthesis are discussed in this review.
- 社団法人日本薬学会の論文
- 1983-08-25
著者
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