Studies on Peptides. CXLI. : Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Porcine GIP (Glucose-Dependent Insulinotropic Polypeptide)
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概要
- 論文の詳細を見る
The dotetracontapeptide corresponding to the revised amino acid sequence of porcine GIP (glucose-dependent insulinotropic polypeptide; originally named gastric inhibitory polypeptide) was synthesized by assembling eight peptide fragments of established purity, followed by thioanisole-mediated deprotection with trifluoromethanesulfonic acid in trifluoroacetic acid. The cycloheptyl esters of aspartic acid and glutamic acid were employed to suppress base-catalyzed side reactions. When tested in dogs, the synthetic peptide produced a significant increase of immunoreactive insulin in blood under background infusion of glucose.
- 社団法人日本薬学会の論文
- 1986-08-25
著者
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藤井 信孝
京都大学薬学部
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細谷 亮
京都大学第一外科
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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野口 正人
Faculty Of Medicine Kyoto University
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水田 和彦
First Department Of Internal Medicine Faculty Of Medicine:kyoto University
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安達 秀樹
University Hospital Faculty Of Medicine Kyoto University
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桜井 満也
Exploratory Chemistry Research, Sankyo Co., Ltd.,
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赤路 健一
Faculty of Pharmaceutical Sciences
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桜井 満也
Exploratory Chemistry Research Sankyo Co. Ltd.
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桜井 満也
Faculty of Pharmaceutical Sciences, Kyoto University
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森賀 本幸
Faculty of Medicine, Kyoto University
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青野 充
Faculty of Medicine, Kyoto University
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水田 和彦
Faculty of Medicine, Kyoto University
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安達 秀樹
Faculty of Medicine, Kyoto University
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井上 一知
Faculty of Medicine, Kyoto University
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細谷 亮
Faculty of Medicine, Kyoto University
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戸部 隆吉
Faculty of Medicine, Kyoto University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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藤井 信孝
京都大学
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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