Studies on Peptides. LXXXIII. Behavior of S-Substituted Cysteine Sulfoxides under Deprotecting Conditions in Peptide Synthesis
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概要
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Sulfoxides of Cys (S-p-methoxybenzyl) and Cys (S-benzyl) were prepared by oxidation with sodium perborate. Hydrogen fluoride and methanesulfonic acid converted the former sulfoxide to S-p-methoxyphenylcysteine or S-p-hydroxyphenylcysteine in the presence of anisole or phenol, respectively, while the latter sulfoxide resisted the actions of these deprotecting reagents. Thiophenol appears to be useful as a powerful reducing reagent for protected cysteine sulfoxides.
- 公益社団法人日本薬学会の論文
- 1979-09-25
著者
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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入江 寛
長崎大薬
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船越 奨
Faculty of Pharmaceutical Sciences
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赤路 健一
Faculty of Pharmaceutical Sciences
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入江 寛
長崎大学薬学部
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入江 寛
Faculty Of Pharmaceutical Sciences Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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