Studies on Peptides. XLIX. Synthesis of the Octadecapeptide corresponding to the Entire Amino Acid Sequence of Porcine β-Melanocyte-stimulating Hormone
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概要
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The octadecapeptide corresponding to the entire amino acid sequence of porcine β-MSH was synthesized by assembling four peptide subunits ; Z (OMe)-Asp (OBzl)-Glu-(OBzl)-Gly-OH (I), Z (OMe)-Pro-Tyr-Lys (Z)-Met-NHNH_2 (II), Z (OMe)-Glu (OBzl)-His-Phe-Arg (Tos)-Trp-Gly-OH (III) and Z (OMe)-Ser-Pro-Pro-Lys (Z)-Asp (OBzl)_2,followed by deblocking of all protecting groups with hydrogen fluoride. The synthetic porcine β-MSH was 3.16 times active than our synthetic human β-MSH (6.2×10^9 MSH unit/g).
- 社団法人日本薬学会の論文
- 1975-02-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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小川 博
Faculty Of Pharmaceutical Sciences Kyoto University
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渡辺 英彦
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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