Synthesis of the Heptadecapeptide Corresponding to the Entire Amino Acid Sequence of Salmon Melanin-Concentrating Hormone (MCH)
スポンサーリンク
概要
- 論文の詳細を見る
The heptadecapeptide corresponding to the entire amino acid sequence of melaninconcentrating hormone (MCH), isolated from chum salmon pituitaries, was synthesized by successive condensation of four peptide fragments and the N-terminal amino acid, i. e., Boc-(14-17)-OBzl, Boc-(9-13)-OH, Boc-(5-8)-NHNH_2,Boc-(2-4)-NHNH_2 and Boc-Asp (OBzl)-OH, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid (TFA) and disulfide formation through the S-sulfonate. When melanin-concentrating activity was measured on a tilapia scale, the minimum effective concentration of the synthetic peptide was equivalent to that of natural salmon MCH (1nM).
- 公益社団法人日本薬学会の論文
- 1984-08-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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安村 貢一
Fujii, Memorial Research Institute, Otsuka Pharmaceutical Co., Ltd.,
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木曽 良明
Kyoto College of Pharmacy
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冨士谷 憲徳
Kyoto College of Pharmacy, 5 Nakauchi-cho, Yamashina
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岡本 憲治
Kyoto Pharmaceutical University
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川内 浩司
School of Fisheries Sciences, Kitasato University
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川内 浩司
School Of Fisheries Science Kitasato University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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安村 貢一
Kyoto College of Pharmacy
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川添 一郎
School of Fisheries Science, Kitasato University
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安村 貢一
Fujii Memorial Research Institute Otsuka Pharmaceutical Co. Ltd.
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冨士谷 憲徳
Kyoto Pharmaceutical University
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