Studies on Peptides. LIX. Synthesis of the Nonatriacontapeptide Corresponding to the Entire Amino Acid Sequence of Porcine Adrenocorticotropic Hormone
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概要
- 論文の詳細を見る
The nonatriacontapeptide corresponding to the newly revised amino acid sequence of porcine adrenocorticotropic hormone (ACTH) was synthesized by successive condensations of 4 peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-OH, Z (OMe)-(5-10)-OH and Z-(1-4)-NHNH_3,with H-(20-39)-OBzl, a synthetic intermediate of porcine corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the identical Rf value with that of natural porcine ACTH in two different solvent systems and its in vivo steroidogenetic activity was 148.2 IU/mg.
- 公益社団法人日本薬学会の論文
- 1976-03-25
著者
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中村 益久
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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木曽 良明
Faculty of Pharmaceutical Sciences, University of Tokushima
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田中 明
Shionogi Research Laboratory Shionogi And Co. Ltd.
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中村 益久
Shionogi Research Laboratories Shionogi & Co. Ltd.
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