Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine
スポンサーリンク
概要
- 論文の詳細を見る
The use of thioanisole as a scavenger was found to suppress a side reaction when the O-protecting groups of tyrosine were deblocked under the acidic conditions. This good result gives a promising outlook for the synthesis of tyrosine-containing peptides by solid-phase method.
- 公益社団法人日本薬学会の論文
- 1978-08-25
著者
-
北川 幸己
徳島大学薬学部
-
北川 幸己
Faculty of Pharmaceutical Sciences, Kyoto University
-
秋田 正
Faculty of Pharmaceutical Sciences, Tokushima University
-
木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
-
木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
-
木曽 良明
Faculty of Pharmaceutical Sciences, University of Tokushima
-
秋田 正
Faculty Of Pharmaceutical Sciences The University Of Tokushima
-
北川 幸己
Faculty Of Pharmaceutical Sciences University Of Tokushima
-
井沢 博子
Faculty of Pharmaceutical Sciences, University of Tokushima
-
井沢 博子
Faculty Of Pharmaceutical Sciences University Of Tokushima
関連論文
- 抗アレルギー薬の研究(第1報)1,2,3-三置換-2-propen-1-one類, 3,4-二置換-4-oxo-2-butenoic Acid類及び関連化合物について
- Studies on Peptides. Application of Trifluoromethanesulphonic Acid as a Deblocking Reagent to the Synthesis of Neurotensin
- Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of α-Form of Rat Calcitonin Gene-Related Peptide (α-rCGRP)(Organic,Chemical)
- Synthesis of Human Renin Inhibitory Peptides, Angiotensinogen Transition-State Analogs Containing a Retro-Inverso Amide Bond
- Synthesis and Structure-Activity Relationships of Human Renin Inhibitors Designed from Angiotensinogen Transition State
- A SIMPLE DIASTEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE AND ALLOCYCLOHEXYLNORSTATINE
- Solution Synthesis of Human Peptide YY (hPYY)
- Solution Synthesis of Human Neuropeptide Y (hNPY)
- 2-Propen-1-one 誘導体の合成と抗真菌活性^
- Studies on Peptides. CXXXVI. : Solution-Phase Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Calcitonin Gene-Related Peptide (hCGRP)
- Tyr-Arg(キョートルフィン)ユニットを持つ新鎮痛性ペンタペプチド、ネオキョートルフィンの牛脳よりの単離(発表論文抄録(1983年))
- Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin
- Synthesis and Analgesic Activity of Neo-kyotorphin Analogs
- Structure-Activity Relationship of Fluorine-Containing Renin Inhibitory Peptides Based upon the Tertiary Structure of Human Renin
- NEW HUMAN RENIN INHIBITORY PEPTIDES : ANGIOTENSINOGEN TRANSITION-STATE ANALOGUES CONTAINING NOVEL LEU-VAL REPLACEMENT AND A RETRO-INVERSO AMIDE BOND
- ウシ脳からの麻酔作用を持つ新たなペンタペプチド, Neo-Kyotorphinの単離
- Studies on Peptides. XLIII. Synthesis of Two Protected Peptides Related to the C-Terminal Portion of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
- A Synthetic Method Suitable for the Rapid Preparation of ^N-Labeled Dermorphin Analogue, H-Try-D-Met(O)-Phe-Gly-NH_2 (SD-62)
- Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements
- A Deblocking Method using Thioether-Sulfonic Acid Systems. Application to the Synthesis of Met-Enkephalin
- Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)
- Studies on Peptides. CXXXVIII. : Conventional Solution Synthesis of Bovine Hypothalamic Growth Hormone Releasing Factor (bGRF)
- Studies on Peptides. CXXXVII. : Conventional Solution Synthesis of Porcine Hypothalamic Growth Hormone Releasing Factor (pGRF)
- Synthesis of Canine Motilin, a Gastric Motor Activity-Stimulating Polypeptide, and Its N^1-Substituted Analogs
- Studies on Peptides. LIX. Synthesis of the Nonatriacontapeptide Corresponding to the Entire Amino Acid Sequence of Porcine Adrenocorticotropic Hormone
- Enzyme Immunoassay of a Substance P-like Immunoreactive Substance in Human Plasma and Saliva
- SOLUTION STRUCTURE OF HIV-1 PROTEASE-ALLOPHENYLNORSTATINE DERIVATIVE INHIBITOR COMPLEX OBTAINED FROM MOLECULAR DYNAMICS SIMULATION
- RATIONAL DESIGN AND SYNTHESIS OF A NOVEL CLASS OF ACTIVE SITE-TARGETED HIV PROTEASE INHIBITORS CONTAINING A HYDROXYMETHYLCARBONYL ISOSTERE. USE OF PHENYLNORSTATINE OR ALLOPHENYLNORSTATINE AS A TRANSITION-STATE MIMIC
- Synthesis of the Heptadecapeptide Corresponding to the Entire Amino Acid Sequence of Salmon Melanin-Concentrating Hormone (MCH)
- NEW HYDROXYL PROTECTING GROUPS OF A SAFETY-CATCH TYPE REMOVABLE BY TEDUCTIVE ACIDOLYSIS
- Fluoren-9-ylmethyloxycarbonyl (Fmoc) Amino Acid Chloride as an Efficient Reagent for Anchoring Fmoc Amino Acid to 4-Alkoxybenzyl Alcohol Resin
- Deprotection of the S-Trimetylacetamidomethyl (Tacm) Group Using Silver Tetrafluoroborate : : Application to the Synthesis of Porcine Brain Natriuretic Peptide-32 (pBNP-32)
- Solution-Phase Synthesis of Porcine Brain Natriuretic Peptide (pBNP) Using S-Trimethylacetamido-methylcysteine
- Trimethylacetamidomethyl (Tacm) Group, a New Protecting Group for the Thiol Function of Cysteine
- SYNTHESIS OF PORCINE BRAIN NATRIURETIC PEPTIDE-32 USING SILVER TETRAFLUOROBORATE AS A NEW DEPROTECTING REAGENT OF THE S-TRIMETHYLACETAMIDOMETHYL GROUP
- EFFICIENT SOLID PHASE PEPTIDE SYNTHESIS ON A PHENACYL-RESIN BY A METHANESULFONIC ACID α-AMINO DEPROTECTING PROCEDURE
- TETRAFLUOROBORIC ACID, A USEFUL DEPROTECTING REAGENT IN PEPTIDE SYNTHESIS
- A FLUORIDE ION DEPROTECTION STRATEGY IN PEPTIDE SYNTHESIS. : COMBINATION WITH SELECTIVE DEPROTECTION USING THE DILUTE METHANESULFONIC ACID OF α-MAINO PROTECTING GROUPS
- Synthesis of the Hexadecapeptide corresponding to Positions 1 through 16 of Porcine Motilin, a Gastric Motor Activity Stimulating Polypeptide
- RACEMIZATION-FREE SYNTHESIS OF C-TERMINAL CYSTEINE-PEPTIDE USING 2-CHLOROTRITYL RESIN
- Synthesis of Rat Brain Natriuretic Peptide 45 Using Tetrafluoroboric Acid Deprotection and Silyl Chloride Disulfide Formation
- KYNOSTATIN (KNI)-227 AND -272,HIGHLY POTENT ANTI-HIV AGENTS : CONFORMATIONALLY CONSTRAINED TRIPEPTIDE INHIBITORS OF HIV PROTEASE CONTAINING ALLOPHENYLNORSTATINE
- KNI-102,A NOVEL TRIPEPTIDE HIV PROTEASE INHIBITOR CONTAINING ALLOPHENYLNORSTATINE AS A TRANSITION-STATE MIMIC
- Solution-Phase Synthesis of α-Rat Atrial Natriuretic Peptide (α-rANP)
- Solution-Phase Synthesis of α-Human Atrial Natriuretic Peptide (α-hANP)
- Studies on Peptides. XXVIII. Synthesis of the Docosapeptide which Embodies the Entire Amino Acid Sequence of β-Melanocyte-stimulating Hormone from Human Pituitary Gland
- Facile Reduction of Methionine Sulfoxide with Sulfur Trioxide/Iodide Ion System
- Solution Syntheses of Two Enkephalin-Containing Peptides, Peptide E and Dynorphin(1-24), Using N^-(2,4,6-Triisopropylphenylsulfonyl)tryptophan
- Alternative Synthesis of Porcine Secretin and Apparent Autolysis of the Product
- SYNTHESIS OF A NEWLY ISOLATED OPIOID TRIDECAPEPTIDE, RIMORPHIN, FROM PITUITARY USING A TRIFLUOROACETIC ACID-THIOANISOLE DEPROTECTION SYSTEM
- Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the N^-Function of Histidine
- Synthesis and Activity of C-Terminal Heptapeptides of Tachykinins and Bombesin-like Peptides
- Synthesis of Two Substance P Analogs, [8-Tyr] and [5-Asn] Substance P
- Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine
- Studies on Peptides. LXV. Conventional Synthesis of a New Hypothalamic Peptide, Bovine Neurotensin
- Studies on Peptides. LXVII. Synthesis of the Hexadecapeptide corresponding to Position 1 through 16 of Porcine Cholecystokinin-Pancreozymin (CCK-PZ)
- Studies on Peptides. L. Acidolysis of Protecting Groups in Peptide Chemistry by Fluorosulphonic Acid and Methanesulphonic Acid
- Alternative Synthesis of Substance P
- Studies on Peptides. LVIII. Synthesis of Tyr^1-Substance P
- ラクトアミドおよびマンデルアミドとアミノ酸およびアミンとの融解反応
- Studies on Peptides. XXXVII. Suppressed Racemization in Peptide Synthesis by the Use of p-Chloro or p-Nitrobenzene-sulfohydroxamic Acid
- Studies on Peptides. XXXVIII. Structure-Activity Correlations in Substance P
- Studies on Peptides. XXXIV. Conventional Synthesis of the Undecapeptide Amide corresponding to the Entire Amino Acid Sequence of Bovine Substance P
- “Safety-catch”型保護基の特性を活用した硫酸化チロシン含有ペプチドの新規合成法の開発
- Evaluation of the Final Deprotection System for the Solid-Phase Synthesis of Tyr(SO_3H)-Containing Peptides with 9-Fluorenylmethyloxycarbonyl (Fmoc)-Strategy and Its Application to the Synthesis of Cholecystokinin (CCK)-12