Synthesis and Analgesic Activity of Neo-kyotorphin Analogs

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概要

• 論文の詳細を見る

• Seven analogs which contain D-amino acids or the sterically hindered amino acid Pro, and two short-chain analogs of neo-kyotorphin (1), an analgesic pentapeptide isolated from bovine brain, were synthesized by the conventional method and screened for analgesic activity. All the analogs exhibited significantly enhanced analgesic effect upon intracisternal administration in mice. In particular, [D-Ser^2]-and [Pro^2]-neo-kyotorphin exhibited almost 10 times more potent activity than neo-kyotorphin.

• 社団法人日本薬学会の論文
• 1985-01-25

著者

• 木山 晋哉

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  徳島大学薬学部

• 北川 幸己

  Faculty of Pharmaceutical Sciences, Kyoto University

• 高木 博司

  京都大学薬学部

• 秋田 正

  Faculty of Pharmaceutical Sciences, Tokushima University

• 木曽 良明

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 木曽 良明

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• 高木 博司

  Faculty Of Pharmaceutical Sciences Kyoto University

• 高木 博司

  京都大学

• 植田 弘師

  Faculty of Pharmaceutical Sciences, Kyoto University

• 河合 伸之

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 植田 弘師

  長崎大学薬学部分子薬理学分野

• 河合 伸之

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 植田 弘師

  長崎大学大学院医歯薬学総合研究科分子薬理学分野

• 木曽 良明

  Kyoto College of Pharmacy

• 葛 鳴

  Faculty of Pharmaceutical Sciences, Kyoto University

• 植田 弘師

  京都大学薬学部薬理

• 葛 鳴

  Faculty Of Pharmaceutical Sciences Kyoto University

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