SOLUTION STRUCTURE OF HIV-1 PROTEASE-ALLOPHENYLNORSTATINE DERIVATIVE INHIBITOR COMPLEX OBTAINED FROM MOLECULAR DYNAMICS SIMULATION
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概要
- 論文の詳細を見る
Structures of two enzyme-inhibitor complexes of human immunodeficiency virus-1 protease with allophenylnorstatine derivatives were obtained from molecular dynamics simulation in aqueous solution. The stronger inhibitor gave considerably smaller fluctuation at P3 site, which formed hydrogen bonding with the enzyme flap region.
- 公益社団法人日本薬学会の論文
- 1994-01-15
著者
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広野 修一
北里大学薬学部
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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木曽 良明
京都薬大
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広野 修一
Department Of Pharmaceutical Sciences Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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高橋 治
Pharmaceuticals & Biotechnology Laboratory Nikko Kyodo Co. Ltd.
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広野 修一
School of Pharmaceutical Sciences, Kitasato University
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加藤 良平
School Of Pharmaceutical Sciences Kitasato University:pharmaceuticals & Biotechnology Laboratory
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森口 郁生
北里大
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Moriguchi I
School Of Pharmaceutical Sciences Kitasato University
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