NEW HYDROXYL PROTECTING GROUPS OF A SAFETY-CATCH TYPE REMOVABLE BY TEDUCTIVE ACIDOLYSIS
スポンサーリンク
概要
- 論文の詳細を見る
New hydroxyl protecting group of a safety-catch type, i.e., 4-methylsulfinylbenzyloxycarbonyl (Msz) group for Tyr and 4-methylsulfinylbenzyl (Msob) ether for Thr, have been developed. O-Msz and O-Msob groups are stable under both acidic and basic conditions and can be removed by a one-pot reaction involving reductive acidolysis using tetrachlorosilane-trifluoroacetic acid (TFA)-scavengers. Using these new protecting groups, a 17 residue-peptide, γ-endorphin, was successfully synthesized by the efficient solid phase method.
- 公益社団法人日本薬学会の論文
- 1991-11-25
著者
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木村 徹
京都薬大
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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木曽 良明
京都薬大
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赤路 健一
京都薬科大学
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赤路 健一
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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田中 茂樹
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木村 徹
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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伊藤 久富
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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田中 茂樹
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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伊藤 久富
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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