NEW HUMAN RENIN INHIBITORY PEPTIDES : ANGIOTENSINOGEN TRANSITION-STATE ANALOGUES CONTAINING NOVEL LEU-VAL REPLACEMENT AND A RETRO-INVERSO AMIDE BOND

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概要

• 論文の詳細を見る

• New human renin inhibitors were designed from transition-state analogues of angiotensinogen, synthesized and evaluated. The peptide derovative, which contained 1-naphthylmethylsuccinylamide residue (P3) with a retro-inverso amide bond and a norstatine isoamylamide residue (P1-P1'), was stable to proteases and had potent human renin inhibitory activity. This compact inhibitor exhibited hypotension when administered orally to a monkey.

• 社団法人日本薬学会の論文
• 1988-06-25

著者

• 赤羽 健司

  キッセイ薬品工業株式会社中央研究所

• 原田 弘

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 飯塚 欣二

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 上條 哲聖

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 赤羽 健司

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 久保田 哲弘

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 島岡 巌

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 梅山 秀明

  School of Pharmaceutical Sciences, Kitasato University

• 木曽 良明

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 上條 哲聖

  キッセイ薬品工業株式会社中央研究所

• 上条 哲聖

  キッセイ薬品工業中央研究所

• 久保田 哲弘

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• 梅山 秀明

  School Of Pharmaceutical Sciences Kitasato University

• 飯塚 欣二

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• 木曽 良明

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• 原田 弘

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• 島岡 巌

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• 赤羽 健司

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

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