A NEW METHOD FOR CALCULATING HYDROPHOBIC INTERACTION ENERGY IN THE BIOLOGICAL SYSTEM
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概要
- 論文の詳細を見る
A method is proposed to estimate the hydrophobic interaction energy for the binding of a ligand to an enzyme. The hydrophobic energy for the association of methotrexate and dihydrofolate reductase was estimated by this method. Compensations were found between the hydrophobic and the electrostatic energies for the constituent functional groups in methotrexate. The association may be unfavorable from the viewpoint of hydrophobicity; it may be electrostatically driven.
- 社団法人日本薬学会の論文
- 1986-08-25
著者
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赤羽 健司
キッセイ薬品工業株式会社中央研究所
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赤羽 健司
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,
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梅山 秀明
School of Pharmaceutical Sciences, Kitasato University
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梅山 秀明
School Of Pharmaceutical Sciences Kitasato University
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赤羽 健司
School of Pharmaceutical Sciences, Kitasato University
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赤羽 健司
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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