Molecular Orbital Study of Lactate Dehydrogenase

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概要

• 論文の詳細を見る

• The mechanism of the enzymatic reaction of lactate dehydrogenase was studied from the quantum chemical point of view. The charge relay system composed of aspartate, histidine and lactate of the substrate or pyruvate enol of the inhibitor was assumed. The substrate or the inhibitor played a role as a proton donor like serine in the "charge relay system"of α-chymotrypsin. Moreover arginine 171 for the assumed charge relay system was very significant in order to lower the potential barrier of the proton transfer from the substrate or the inhibitor to histidine 195. Last the significance of the HOMOLUMO interaction between the substrate or the inhibitor and nicotinamide in NAD^+was shown.

• 社団法人日本薬学会の論文
• 1977-07-25

著者

• 梅山 秀明

  School of Pharmaceutical Sciences, Kitasato University

• 梅山 秀明

  School Of Pharmaceutical Sciences Kitasato University

• 中川 節子

  School of Pharmaceutical Sciences, Kitasato University

• 永田 親義

  Biophysics Division, National Cancer Center Research Institute

• 中川 節子

  北里大学薬学部

• 中川 節子

  School Of Pharmaceutical Sciences Kitasato University

• 永田 親義

  国立がんセンター研究所生物物理部

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