Electrostatic Potential Images of Drugs Targetting Dopamine Receptors
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概要
- 論文の詳細を見る
The electrostatic potentials of five drugs targetting dopamine receptors were calculated on the molecular surface, or the solvent-accessible surface, using Cartesian coordinates and Mulliken net atomic charges obtained by the use of semi-empirical molecular orbital method, modified neglect of diatomic overlap. All of these electrostatic potential images, which were represented by color-coded graphics, showed the interesting feature that a positive potential region exists on one side of the molecular surface. This may reflect the specific orientation of the drug molecules for binding to dopamine receptors, which presumably show electrostatic and topographic complementarity.
- 社団法人日本薬学会の論文
- 1984-08-25
著者
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梅山 秀明
School of Pharmaceutical Sciences, Kitasato University
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梅山 秀明
School Of Pharmaceutical Sciences Kitasato University
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広野 修一
Department Of Pharmaceutical Sciences Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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広野 修一
School of Pharmaceutical Sciences, Kitasato University
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