Structure-Activity Studies of 3-Benzoylpropionic Acid Derivatives Suppressing Adjuvant Arthritis
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概要
- 論文の詳細を見る
3-Benzoylpropionic acid derivatives possess an immunomodulative activity and suppress adjuvant arthritis. To understand how substitutents affect the biological activity, the quantitative structure-activity relationships of 30 compounds were analyzed by the adaptive least-squares method. For the suppressing activity in rats, the electronic effects and the structural feature of the substituent on benzene ring were suggested to be important. To reinforce and confirm the correlation, 4 additional compounds of phenoxybutyric acid derivatives were synthesized and tested with the rat sdjuvant-induced arthritis. These compounds were found to have potent suppressing activity.
- 公益社団法人日本薬学会の論文
- 1992-03-25
著者
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広野 修一
北里大学薬学部
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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川島 豊
Research Center Taisho Pharmaceutical Co. Ltd.
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川島 豊
大正製薬・総合研
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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広野 修一
Department Of Pharmaceutical Sciences Kitasato University
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亀尾 一弥
Research Center, Taisho Pharmaceutical Co., Ltd.,
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富沢 一雪
Research Center, Taisho Pharmaceutical Co., Ltd.,
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加藤 美幸
Research Center Taisho Pharmaceutical Co. Ltd.
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森口 郁生
北里大
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長谷川 昌弘
Research Center, Taisho Pharmaceutical Co., Ltd.
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広野 修一
Schhol of Pharmaceutical Sciences, Kitasato University
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森口 郁生
Schhol of Pharmaceutical Sciences, Kitasato University
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冨沢 一雪
Research Center Taisho Pharmaceutical Co. Ltd.
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亀尾 一弥
Research Center Taisho Pharmaceutical Co. Ltd.
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富沢 一雪
Research Center Taisho Pharmaceutical Co. Ltd.
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長谷川 昌弘
Research Center Taisho Pharmaceutical Co. Ltd.
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Moriguchi I
School Of Pharmaceutical Sciences Kitasato University
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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