Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Derivatives Containing Nitrooxyalkylester Moieties at the 3- and 5-Positions
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概要
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We have synthesized new 1,4-dihydropyridine derivatives having nitrooxyalkylester moieties at the 3- and 5-positions in order to develop potent and long-lasting vasodilators. The antihypertensive activities of these compounds were compared with that of nifedipine. One of them, 2-nitrooxypropyl 3-nitrooxypropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate (CD-349) was selected for further development. The structure-activity relationship is discussed.
- 社団法人日本薬学会の論文
- 1993-06-15
著者
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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土田 勝晴
Research Center Taisho Pharmaceutical Co. Ltd.
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中里 篤郎
Research Center Taisho Pharmaceutical Co. Ltd.
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小川 利寿
Research Center, Taisho Pharmaceutical Co., Ltd.,
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小川 利寿
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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