Synthesis and Pharmacological Evaluation of 1,2,3,4-Tetrahydro-β-carboline Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of 1,2,3,4-tetrahydro-β-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3,5-dimethoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-β-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.
- 公益社団法人日本薬学会の論文
- 1995-05-15
著者
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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川島 豊
Research Center Taisho Pharmaceutical Co. Ltd.
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川島 豊
大正製薬・総合研
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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唐沢 康子
大正製薬(株)医薬研究所
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唐沢 康子
Research Center, Taisho Pharmaceutical Co., Ltd.,
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荒木 博陽
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田口 稔
Research Center, Taisho Pharmaceutical Co., Ltd.,
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堀口 亜生代
Research Center, Taisho Pharmaceutical Co., Ltd.,
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露木 佳美
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田口 稔
Research Center Taisho Pharmaceutical Co. Ltd.
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露木 佳美
Research Center Taisho Pharmaceutical Co. Ltd.
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Karasawa Y
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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堀口 亜生代
Research Center Taisho Pharmaceutical Co. Ltd.
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