Studies on Topical Antiinflammatory Agents. IV., : 21-(Alkylthio)acetates and (Methylthio)methoxides of Corticosteroids
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概要
- 論文の詳細を見る
A series of 21-(alkylthio)acetates and 21-(methylthio)methoxides of corticosteroids were synthesized and examined for vasoconstrictive activities. The activities of seven compounds were equal to or greater than that of 9α-fluoro-11β, 21-dihydroxy-16β-methyl-17α-valeryloxy-1,4-pregnadiene-3,20-dione (betamethasone 17-valerate, BV). Among them, betamethasone 21-(methylthio)acetate 17-propanoate (2Ca) was found to have the most potent activity, which is superior to that of BV. A structure-activity relationship study revealed that substitution of the 21-hydroxy group of corticosteroids with the (methylthio)acetate function is a useful approach for obtaining potent activity.
- 公益社団法人日本薬学会の論文
- 1990-03-25
著者
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安井 一
Research Center Taisho Pharmaceutical Co. Ltd.
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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樋口 昭平
Research Center Taisho Pharmaceutical Co. Ltd.
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三口 守公
Research Center, Taisho Pharmaceutical Co., Ltd.,
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池本 知之
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田口 稔
Research Center, Taisho Pharmaceutical Co., Ltd.,
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阿部 訓志
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田口 稔
Research Center Taisho Pharmaceutical Co. Ltd.
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池本 知之
Research Center Taisho Pharmaceutical Co. Ltd.
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三口 守公
Research Center Taisho Pharmaceutical Co. Ltd.
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阿部 訓志
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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